Orthotopic Models of Pancreatic Cancer to Study PDT.
Orthotopic Models of Pancreatic Cancer to Study PDT.
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DOI：
10.1007/978-1-0716-2099-1_12
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发表时间：
2022
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胰腺导管腺癌（PDAC）的一个标志是其预后差，这是由于对治疗的显著抵抗、侵袭性和高转移潜力。光动力疗法（PDT）是一种有前途的模式，有效地管理PDAC的临床前和临床。虽然PDT用于PDAC的临床试验仍处于早期阶段，但大量优雅的临床前研究正在支持基于PDT的治疗方案的转化和临床采用，其中许多方案利用PDAC的原位临床前模型。鉴于疾病的侵袭性在很大程度上取决于PDAC肿瘤的定位，因此用于评估基于PDT的治疗方案的临床前模型必须重现自然发病机制的要素，以便设计针对具有最高临床成功潜力的PDAC的治疗方案。鉴于临床相关的PDAC模型的重要性，本章将详细介绍和讨论在过去三十年中开发的方法，以利用原位PDAC模型，以评估基于PDT的治疗方案。这些缺点也将被讨论，除了未来的方向，该领域正在走向建立最相关的原位模型的PDAC。
A hallmark of Pancreatic Ductal Adenocarcinoma (PDAC) is its poor prognosis that stems from a marked resistance to therapy, an invasive nature and a high metastatic potential. Photodynamic therapy (PDT) is a promising modality for effectively managing PDAC both pre-clinically and clinically. Whilst clinical trials of PDT for PDAC are still in their early stages, a plethora of elegant pre-clinical studies are supporting the translation and clinical adoption of PDT-based treatment regimens, many of which leverage orthotopic preclinical models of PDAC. Given the aggressiveness of the disease that is largely dependent on the localization of PDAC tumors, it is imperative that preclinical models used to evaluate PDT-based treatment regimens recapitulate elements of the natural pathogenesis in order to design treatment regimens tailored to PDAC with the highest potential for clinical success. In light of the importance of clinically-relevant models of PDAC, this chapter will detail and discuss the methodologies developed over the last three decades to leverage orthotopic PDAC models in order to evaluate PDT-based treatment regimens. The shortcomings of these will also be discussed, in addition to the future directions that the field is headed to establish the most relevant orthotopic models of PDAC.