Polyethylenimine-based micro/nanoparticles as vaccine adjuvants.
Polyethylenimine-based micro/nanoparticles as vaccine adjuvants.
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聚乙烯亚胺基微/纳米粒子作为疫苗佐剂
DOI：
10.2147/ijn.s137980
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发表时间：
2017
影响因子：
8
通讯作者：
Tao J
中科院分区：
文献类型：
--
作者：
Shen C;Li J;Zhang Y;Li Y;Shen G;Zhu J;Tao J
疫苗在治疗和预防肿瘤和感染方面取得了巨大成功，而佐剂总是需要确保有效的免疫反应。聚乙烯亚胺（PEI）作为一种阳离子高分子材料，作为转染试剂已经有几十年的历史。然而，越来越多的证据表明，基于PEI的颗粒也能够充当佐剂。本文简要介绍了PEI的理化性质及其在不同领域的广泛应用，并详细阐述了PEI疫苗的细胞内过程。此外，我们总结了它们在体内和临床应用的证据。我们还强调了PEI内在免疫激活功能的一些机制，其次是PEI在疫苗中应用的挑战和未来前景，以及引发理想的免疫应答的一些策略。
Vaccines have shown great success in treating and preventing tumors and infections, while adjuvants are always demanded to ensure potent immune responses. Polyethylenimine (PEI), as one of the well-studied cationic polymers, has been used as a transfection reagent for decades. However, increasing evidence has shown that PEI-based particles are also capable of acting as adjuvants. In this paper, we briefly review the physicochemical properties and the broad applications of PEI in different fields, and elaborate on the intracellular processes of PEI-based vaccines. In addition, we sum up the proof of their in vivo and clinical applications. We also highlight some mechanisms proposed for the intrinsic immunoactivation function of PEI, followed by the challenges and future perspectives of the applications of PEI in the vaccines, as well as some strategies to elicit the desirable immune responses.