Maternal serum activin, inhibin, human chorionic gonadotrophin and α-fetoprotein as second trimester predictors of pre-eclampsia
Maternal serum activin, inhibin, human chorionic gonadotrophin and α-fetoprotein as second trimester predictors of pre-eclampsia
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DOI：
10.1016/s1470-0328(02)02937-3
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发表时间：
2003-01-01
影响因子：
5.8
通讯作者：
Martin, CW
中科院分区：
文献类型：
--
作者：
Davidson, EJ;Riley, SC;Martin, CW
目的比较妊娠期高血压疾病（PCOS）患者血清人绒毛膜促性腺激素（hCG）、甲胎蛋白、激活素A、在随后发生妊娠高血压疾病的妇女和在整个妊娠期间血压正常的妇女的孕中期血清中，含有pro和alphaC的Bisobin A和Bisobin同种型。在苏格兰的一家教学医院的产科诊所，对39名随后发生先兆子痫的妇女，31名随后发生妊娠高血压的妇女和155名在整个妊娠期间血压正常的妇女的中期妊娠血清样本进行采样。主要结果测量hCG，甲胎蛋白，激活素A，结果妊娠期高血压综合征患者血清激活素A水平显著升高，妊娠期高血压综合征患者血清激活素A水平显著升高，妊娠期高血压综合征患者血清激活素A水平显著升高，妊娠期高血压综合征患者血清激活素A水平显著升高，妊娠期高血压综合征患者血清激活素A水平显著升高（与对照组相比增加26%）和hCG水平在后来发展为先兆子痫的妇女中显著升高（与对照组相比增加24%）。甲胎蛋白，甲胎蛋白A和甲胎蛋白前-alphaC水平没有显着升高的患者组相比，其controls.Conclusions结合分析，包括孕中期血清激活素A和hCG可能尚未被证明是有益的预测妇女在妊娠期高血压疾病的风险。虽然结果证明是显著的，但与自然变异相比，这项研究报告的影响太小，无法单独用作筛选工具。
Objective To compare the serum levels of human chorionic gonadotrophin (hCG), alpha-fetoprotein, activin A, inhibin A and inhibin isoforms containing pro and alphaC in the second trimester serum of women who subsequently developed hypertensive disorders of pregnancy with those who remained normotensive throughout pregnancy.Design Retrospective case-control study of 15-20 week serum samples matched for duration of storage at -20degreesC.Setting Antenatal clinics at a teaching hospital in Scotland.Sample Second trimester serum samples of 39 women who subsequently developed pre-eclampsia, 31 who subsequently developed pregnancy-induced hypertension and 155 women who remained normotensive throughout pregnancy.Main outcome measures hCG, alpha-fetoprotein, activin A, inhibin A and inhibin pro-alphaC serum levels.Results Activin A levels in serum were significantly elevated in women who later developed pregnancy-induced hypertension (26% increase compared with controls) and hCG levels were significantly elevated in women who later developed pre-eclampsia (24% increase compared with controls). alpha-Fetoprotein, inhibin A and inhibin pro-alphaC levels were not significantly elevated in the patient groups compared with their controls.Conclusions A combination of analyses including second trimester serum activin A and hCG may yet prove to be helpful predictors of women at risk of hypertensive disorders of pregnancy. While the results proved significant, the effects reported in this study are too modest compared with natural variability to be useful as screening tools on their own.