Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia
Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia
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DOI：
10.1016/j.schres.2015.06.021
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发表时间：
2016-06-01
影响因子：
4.5
通讯作者：
Pol, Hilleke E. Hulshoff
中科院分区：
文献类型：
--
作者：
Hedman, Anna M.;van Haren, Neeltje E. M.;Pol, Hilleke E. Hulshoff
背景：在精神分裂症中反复发现皮质厚度和表面积的变化。皮质厚度和表面积的逐渐丧失是否是由遗传或疾病相关因素介导尚不清楚。在这里，我们调查遗传和/或环境因素在多大程度上影响皮质厚度和表面积的变化与患精神分裂症的可能性之间的关联。方法：为期 5 年的纵向磁共振成像研究。使用重复测量方差分析（RM-ANOVA）和结构方程模型（SEM）将精神分裂症不一致的同卵（MZ）和双卵（DZ）双胞胎与健康对照双胞胎进行比较。精神分裂症不一致的双胞胎和健康对照双胞胎是从荷兰乌得勒支大学医学中心的双胞胎队列中招募的。共纳入 46 对同性双胞胎中的 90 人：9 名同卵双胞胎和 10 名异卵双胞胎患有精神分裂症，14 名同卵双胞胎和 13 名（11 名完整的和 2 名不完整的）异卵双胞胎为健康双胞胎。年龄在 19 岁至 57 岁之间。结果：精神分裂症的较高遗传倾向与大脑皮层（尤其是左上颞叶皮层）的逐渐变薄有关。精神分裂症的较高环境责任与大脑皮层（包括左上颞叶皮层）的整体减薄变薄有关。皮质表面积的变化是可遗传的，但与精神分裂症的较高遗传或环境倾向没有显着相关性。结论：皮质过度变薄，特别是左上颞叶皮质，可能代表精神分裂症的遗传风险标记。 (C) 2015 Elsevier B.V. 保留所有权利。
Background: Cortical thickness and surface area changes have repeatedly been found in schizophrenia. Whether progressive loss in cortical thickness and surface area are mediated by genetic or disease related factors is unknown. Here we investigate to what extent genetic and/or environmental factors contribute to the association between change in cortical thickness and surface area and liability to develop schizophrenia.Method: Longitudinal magnetic resonance imaging study over a 5-year interval. Monozygotic (MZ) and dizygotic (DZ) twin pairs discordant for schizophrenia were compared with healthy control twin pairs using repeated measures analysis of variance (RM-ANOVA) and structural equation modeling (SEM). Twins discordant for schizophrenia and healthy control twins were recruited from the twin cohort at the University Medical Centre Utrecht, The Netherlands. A total of 90 individuals from 46 same sex twin pairs were included: 9 MZ and 10 DZ discordant for schizophrenia and 14 MZ and 13 (11 complete and 2 incomplete) DZ healthy twin-pairs. Age varied between 19 and 57 years.Results: Higher genetic liability for schizophrenia was associated with progressive global thinning of the cortex, particularly of the left superior temporal cortex. Higher environmental liability for schizophrenia was associated with global attenuated thinning of the cortex, and including of the left superior temporal cortex. Cortical surface area change was heritable, but not significantly associated with higher genetic or environmental liability for schizophrenia.Conclusions: Excessive cortical thinning, particularly of the left superior temporal cortex, may represent a genetic risk marker for schizophrenia. (C) 2015 Elsevier B.V. All rights reserved.