Electronic Cigarette Use Is Not Associated with COVID-19 Diagnosis.
Electronic Cigarette Use Is Not Associated with COVID-19 Diagnosis.
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DOI：
10.1177/21501327211024391
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发表时间：
2021-01
影响因子：
3.6
通讯作者：
Warner DO
中科院分区：
文献类型：
--
作者：
Jose T;Croghan IT;Hays JT;Schroeder DR;Warner DO
该分析验证了一种假设，即目前使用电子烟与寻求医疗服务的患者感染SARS-CoV-2的风险增加有关。使用新型电子健康记录工具确定电子烟和传统卷烟的使用情况，并通过经过验证的机构注册表确定COVID-19诊断。拟合逻辑回归模型来评估当前电子烟使用是否与COVID-19诊断风险增加相关。在2019年9月15日至2020年11月30日期间，共有69264名12岁以上、吸烟或吸电子烟的患者在梅奥诊所接受了治疗。平均年龄51.5岁，女性占62.1%，白人占86.3%；11.1%的人目前吸烟或使用电子烟，5.1%的人新冠病毒检测呈阳性。仅使用电子烟的患者不太可能被诊断为COVID-19 (OR 0.93 [0.69-1.25], P =。628)，而只吸烟的人风险降低（OR 0.43 [0.35-0.53], P < 0.001）。双用户的OR值介于这两个值之间（OR = 0.67 [0.49-0.92], P = 0.013）。尽管有充分证据表明电子烟有潜在的危害，但它们似乎不会增加对SARS-CoV-2感染的易感性。这一结果表明，传统吸烟对易感性的任何有益影响都不是由尼古丁介导的。
This analysis tested the hypothesis that current e-cigarette use was associated with an increased risk of SARS-CoV-2 infection in patients seeking medical care. E-cigarette and conventional cigarette use were ascertained using a novel electronic health record tool, and COVID-19 diagnosis was ascertained by a validated institutional registry. Logistic regression models were fit to assess whether current e-cigarette use was associated with an increased risk of COVID-19 diagnosis. A total of 69,264 patients who were over the age of 12 years, smoked cigarettes or vaped, and were sought medical care at Mayo Clinic between September 15, 2019 and November 30, 2020 were included. The average age was 51.5 years, 62.1% were females and 86.3% were white; 11.1% were currently smoking cigarettes or using e-cigarettes and 5.1% tested positive for SARS-CoV-2. Patients who used only e-cigarettes were not more likely to have a COVID-19 diagnosis (OR 0.93 [0.69-1.25], P = .628), whereas those who used only cigarettes had a decreased risk (OR 0.43 [0.35-0.53], P < .001). The OR for dual users fell between these 2 values (OR 0.67 [0.49-0.92], P = .013). Although e-cigarettes have the well-documented potential for harm, they do not appear to increase susceptibility to SARS-CoV-2 infection. This result suggests the hypothesis that any beneficial effects of conventional cigarette smoking on susceptibility are not mediated by nicotine.