Subversion of host cell signalling by the protozoan parasite Leishmania
Subversion of host cell signalling by the protozoan parasite Leishmania
复制标题
DOI：
10.1017/s0031182005008139
复制
发表时间：
2005-01-01
期刊：
影响因子：
2.4
通讯作者：
Olivier, M
中科院分区：
文献类型：
--
作者：
Gregory, DJ;Olivier, M
利什曼原虫属（Leishmania spp.）是专性细胞内寄生虫，栖息在其宿主的巨噬细胞中。由于巨噬细胞专门用于识别和破坏入侵病原体，直接和通过触发先天免疫反应，利什曼原虫已经进化出许多抑制一些关键巨噬细胞活性的机制。在这篇综述中，我们讨论了不同种类的利什曼原虫如何扭曲宿主巨噬细胞自身的信号通路，抑制各种细胞因子和杀微生物分子（一氧化氮和活性氧）的表达，和抗原呈递。特别是，我们描述了MAP激酶和JAK/STAT级联是如何被抑制的，细胞内Ca 2+和蛋白酪氨酸磷酸酶，特别是SHP-1的活性升高。
The protozoa Leishmania spp. are obligate intracellular parasites that inhabit the macrophages of their host. Since macrophages are specialized for the identification and destruction of invading pathogens, both directly and by triggering an innate immune response, Leishmania have evolved a number of mechanisms for suppressing some critical macrophage activities. In this review, we discuss how various species of Leishmania distort the host macrophage's own signalling pathways to repress the expression of various cytokines and microbicidal molecules (nitric oxide and reactive oxygen species), and antigen presentation. In particular, we describe how MAP Kinase and JAK/STAT cascades are repressed, and intracellular Ca2+ and the activities of protein tyrosine phosphatases, in particular SHP-1, are elevated.