Long-Term Follow-Up of Children Treated With the Modified Atkins Diet
Long-Term Follow-Up of Children Treated With the Modified Atkins Diet
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DOI：
10.1177/0883073812441062
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发表时间：
2012-06-01
影响因子：
1.9
通讯作者：
Kossoff, Eric H.
中科院分区：
文献类型：
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作者：
Chen, Wendy;Kossoff, Eric H.
改良的阿特金斯饮食已经在大多数短期临床试验和病例系列中进行了研究。没有研究系统地检查长期益处和副作用。自2002年以来，在约翰霍普金斯医院的87名儿童中开始了改良的阿特金斯饮食，而之前没有使用生酮饮食，其中54人持续了6个月以上。通过电话和电子邮件联系了过去2年内没有见过的儿童。在最近的一次改良阿特金斯饮食（平均19.9个月）中，54名饮食持续时间超过6个月的儿童中有30名（55%）获得了> 50%的改善; 19名（35%）没有肥胖。使用意向治疗分析，在12个月时，87例患者中有33例（38%）癫痫发作减少> 50%; 16例（18%）无癫痫发作。这些结果与短期改良阿特金斯饮食和长期生酮饮食使用的已发表数据相似。副作用主要是血脂升高和胃肠道不适。
The modified Atkins diet has been studied in mostly short-term clinical trials and case series. No studies have systematically examined the long-term benefits and side effects. The modified Atkins diet was started without prior ketogenic diet use in 87 children at the Johns Hopkins Hospital since 2002, of which 54 continued for more than 6 months. Children who had not been seen within the past 2 years were contacted by phone and email. At their most recent point during the modified Atkins diet (mean 19.9 months), 30 of 54 (55%) children with diet durations of more than 6 months achieved > 50% improvement; 19 (35%) were seizure-free. Using an intent-to-treat analysis, at 12 months, 33 of 87 (38%) had > 50% seizure reduction; 16 (18%) were seizure-free. These results are similar to published data for short-term modified Atkins diet and long-term ketogenic diet use. Side effects were predominantly elevations in lipid profile and gastrointestinal upset.