Radiolytic reduction characteristics of artificial oligodeoxynucleotides possessing 2-oxoalkyl group or disulfide bonds.
Radiolytic reduction characteristics of artificial oligodeoxynucleotides possessing 2-oxoalkyl group or disulfide bonds.
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DOI：
10.4061/2011/816207
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发表时间：
2011
影响因子：
2.3
通讯作者：
Nishimoto S
中科院分区：
文献类型：
--
作者：
Tanabe K;Ito T;Nishimoto S
修饰的寡脱氧核苷酸（ODNs）的化学或物理性质受外界刺激的控制，其研究取得了许多进展。这些智能ODNs有望用于下一代基因诊断和治疗。本文主要介绍了X射线激活的人工ODNs的分子设计及其在调控杂交特性、构象变化、辐射激活DNA酶和诱饵分子等方面的应用。
A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules.