Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck.
Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck.
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顺铂和5-FU输注作为晚期头颈部鳞状细胞癌初始治疗的临床试验。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
M. al
中科院分区：
文献类型：
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作者：
J. Kish;A. Drelichman;J. Jacobs;J. Hoschner;J. Kinzie;J. Loh;A. Weaver;M. al
最初的治疗与药物组合，包括顺铂和博来霉素已有效地减少肿瘤的患者先前未经治疗的表皮样癌的头部和颈部。由于博莱霉素肺部并发症的威胁，肺功能差的患者被排除在这些研究之外。我们进行了一项试验，使用顺铂（100 mg/m2）和5-FU（1000 mg/m2/天）96小时输注的组合，并在26例患者中获得了88.5%的有效率，治疗两个疗程。其中5例患者完全缓解，18例部分缓解。恶心和呕吐（70%的患者发生）是主要的毒性反应，26%的患者发生白细胞减少症。虽然所有患者最初都不能手术，但6例在化疗后进行了切除，另外6例在化疗和放疗后进行了切除。另外两名患者在化疗后临床完全缓解后接受放射治疗，另有10名患者在化疗后接受X射线治疗。顺铂和5-FU输注在既往未经治疗的晚期头颈部癌患者中是有效的，而没有博来霉素的毒性。
Initial treatment with drug combinations that include cisplatin and bleomycin has been effective in reducing tumor in patients with previously untreated epidermoid cancers of the head and neck. Because of the threat of pulmonary complications from bleomycin, patients with poor pulmonary function were excluded from those studies. We conducted a trial using the combination of cisplatin (100 mg/m2) and a 96-hour infusion of 5-FU (1000 mg/m2/day) and achieved a response rate of 88.5% in 26 patients treated with two courses. Five of these patients had complete remissions and 18 had partial remissions. Nausea and vomiting (experienced by 70% of the patients) was the predominant toxic effect, and 26% experienced leukopenia. Although all patients were initially inoperable, six underwent resection following chemotherapy, and another six underwent resection after chemotherapy and irradiation. Two additional patients were treated with radiation therapy after clinically achieving complete remissions following chemotherapy, and another ten received X-ray therapy after chemotherapy. Cisplatin and 5-FU infusion are effective without being as toxic as bleomycin in patients with previously untreated advanced carcinoma of the head and neck.