WORK ACTIVITY AND CORONARY HEART MORTALITY
WORK ACTIVITY AND CORONARY HEART MORTALITY
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DOI：
10.1056/nejm197503132921101
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发表时间：
1975-01-01
影响因子：
158.5
通讯作者：
HALE, WE
中科院分区：
文献类型：
--
作者：
PAFFENBARGER, RS;HALE, WE
为了评估体力活动在降低码头工人冠状动脉死亡率中的作用，对6351名年龄在35岁至74岁之间的男性进行了长达22年的跟踪调查，直至死亡或75岁。他们的长线作业经验是根据高、中、低卡路里输出的类别以工作年数计算的。每年对个人工作分配进行重新分类，以考虑到工作调动的影响。高活动组的年龄调整后冠状动脉死亡率为26.9/万工作年，中、低活动组的死亡率分别为46.3和49.0，两者差异不大。这种保护性的“临界值”效应在猝死综合症中尤为明显，重型工人的死亡率为5.6，而中度工人为19.9，轻型工人为15.7。我们的结论是，反复的高能量输出建立了防止冠状动脉死亡的平台，几种不同的机制可以解释这一发现。(N Engl J Med 292：545-550,1975)
To appraise the role of physical activity in reducing coronary mortality among longshoremen, 6351 men, 35 to 74 years old upon entry, were followed for 22 years or to death or to the age of 75. Their longshoring experience was computed in terms of work-years according to categories of high, medium and low caloric output. Individual work assignments were reclassified annually to allow for effect of job transfers. The age-adjusted coronary death rate for the high-activity category was 26.9 per 10,000 work-years, and the medium and low categories had rates of 46.3 and 49.0, which were little different from each other. This protective "threshold" effect was seen especially for the sudden-death syndrome, in which the death rate for heavy workers was 5.6, as contrasted with 19.9 for moderate and 15.7 for light workers. We conclude that repeated bursts of high energy output established a plateau of protection against coronary mortality, and that several different mechanisms may explain this finding. (N Engl J Med 292:545–550, 1975)