Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Urinary levels of 30 metal/metalloids in the Brazilian southeast population: Findings from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
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DOI：
10.1016/j.envres.2023.115624
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发表时间：
2023-03
影响因子：
8.3
通讯作者：
Fernando Barbosa;Paula Pícoli Devóz;Marcos Rafael Nogueira Cavalcante;M. Gallimberti;J. C. Cruz;J. Domingo;E. Simões;P. Lotufo;Simin Liu;I. Benseñor
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作者：
Fernando Barbosa;Paula Pícoli Devóz;Marcos Rafael Nogueira Cavalcante;M. Gallimberti;J. C. Cruz;J. Domingo;E. Simões;P. Lotufo;Simin Liu;I. Benseñor
评估与金属/类金属环境接触相关的风险需要为每个人群制定明确的参考值，因为根据不同的地方/区域特征，参考值有很大差异。然而，很少有研究确定这些元素（必需的和有毒的）在大量人口群体中的基线值，特别是在拉丁美洲国家。本研究旨在确定30种金属/类金属的尿液参考水平：铝（Al）、锑（Sb）、砷（As）、钡（Ba）、铍（Be）、镉（Cd）、铈（Ce）、铯（Cs）、铬（Cr）、钴（Co）、铜（Cu）、镧（La）、铅（Pb）、锂（Li）、锶（Sr）、锰（Mn）、汞（Hg），钼（Mo）、镍（Ni）、铂（Pt）、铷（Rb）、硒（Se）、银（Ag）、锡（Sn）、碲（Te）、铊（Tl）、钍（Th）、钨（W）、铀（U）和锌（Zn）。这项试点研究是一项横断面分析，采用ELSA巴西队列的第一波（基线检查）。本研究共纳入996名成人（45.5%男性，N= 453，平均年龄：50.5岁; 54.5%女性，N= 543，平均年龄：50.6岁）。通过电感耦合等离子体质谱法（ICP-MS）进行样品分析。根据性别列出研究中各元素（μ g/g肌酐）的百分位数（2.5、10、25、50、75、95（CI 95%）和97.5）。此外，根据年龄，教育，吸烟和饮酒的平均金属/类金属尿水平的差异也提出。最后，中值发现值进行了比较，以前在北美和法国进行的大型人体生物监测调查的既定价值。这是第一项全面和系统的人体生物监测研究，确定了巴西人口群体中30种（必需和/或有毒元素）的人口参考范围。
The assessment of risks associated with environmental exposure to metals/metalloids requires well-established reference values for each population since it varies considerably according to distinct local/regional characteristics. However, very few studies establish baseline values for these elements (essential and toxic) in large population groups, especially in Latin American countries. This study was aimed at establishing urinary reference levels of 30 metals/metalloids: aluminum (Al), antimony (Sb), arsenic (As), barium (Ba), beryllium (Be), cadmium (Cd), cerium (Ce), cesium (Cs), chromium (Cr), cobalt (Co), copper (Cu), lanthanum (La), lead (Pb), lithium (Li), strontium (Sr), manganese (Mn), mercury (Hg), molybdenum (Mo), nickel (Ni), platinum (Pt), rubidium (Rb), selenium (Se), silver (Ag), tin (Sn), tellurium (Te), thallium (Tl), thorium (Th), tungsten (W), uranium (U) and zinc (Zn) in a Brazilian southeast adult population. This pilot study is a cross-sectional analysis conducted with the first wave of the ELSA-Brasil cohort (baseline examination). A total of 996 adults (45.5% men, N= 453, mean age: 50.5, and 54.5% women, N= 543, mean age: 50.6) were included in the study. Sample analyses were performed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Percentiles (2.5, 10, 25, 50, 75, 95 (CI95%), and 97.5) of each element (mu g/g of creatinine) in the study are presented according to sex. Moreover, differences in the mean metal/metalloid urinary levels according to age, education, smoking, and alcohol intake are also presented. Finally, median found values were compared to established values of large human biomonitoring surveys previously conducted in North America and France. This is the first comprehensive and systematic human biomonitoring study that established population reference ranges for 30 (essential and/or toxic elements) in a Brazilian population group.