Three-dimensional stereotactic surface projection of brain perfusion SPECT improves diagnosis of Alzheimer’s disease
Three-dimensional stereotactic surface projection of brain perfusion SPECT improves diagnosis of Alzheimer’s disease
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脑灌注 SPECT 三维立体定向表面投影改善阿尔茨海默病的诊断
DOI：
10.1007/bf02984969
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发表时间：
2003
影响因子：
2.6
通讯作者：
M. Oshima
中科院分区：
文献类型：
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作者：
N. Honda;K. Machida;T. Matsumoto;H. Matsuda;E. Imabayashi;J. Hashimoto;M. Hosono;Y. Inoue;K. Koizumi;S. Kosuda;T. Momose;Y. Mori;M. Oshima
目的：阿尔茨海默病 (AD) 通过脑灌注 SPECT 检查或三维立体表面显示 (3D-SSP) 进行诊断。目的是比较这些方法的诊断性能。方法：16 名核医学医师独立解读了 50 项 AD 患者研究和 40 项健康志愿者研究的 99mTc-ECD SPECT（一次）和 SPECT 与 3D-SSP（另一次没有临床信息）。 AD 的概率根据从 0%（正常）到 100%（明确的 AD）的主观量表进行报告。生成接收者操作特征曲线以计算 ROC 曲线下的面积 (Az)，用于检查以及基于 3D-SSP 模板中双侧后扣带回的平均 Z 值的自动诊断。结果：仅 SPECT 目视判读的平均 Az (0.679 ± 0.058) 明显小于 SPECT 和 3D-SSP 目视判读的平均 Az (0.778) ±0.060）。自动诊断的 Az (0.883 ± 0.037) 显着大于两种视觉判读模式的 Az。 结论：3D-SSP 增强了核医学医师检查 SPECT 的表现。自动诊断的性能超过了医生使用或不使用 3D-SSP 检查 SPECT 的性能。
Objectives: Alzheimer’s disease (AD) is diagnosed by either inspection of the brain perfusion SPECT, or three-dimensional stereotactic surface display (3D-SSP). The purpose was to compare diagnostic performances of these methods.Methods: Sixteen nuclear medicine physicians independently interpreted99mTc-ECD SPECT in one session and SPECT with 3D-SSP in another session without clinical information for 50 studies of AD patients and 40 studies of healthy volunteers. Probabilities of AD were reported according to a subjective scale from 0% (normal) to 100% (definite AD). Receiver operating characteristics curves were generated to calculate areas under the ROC curves (Az’s) for the inspection as well as for an automated diagnosis based on a mean Z value in the bilateral posterior cingulate gyri in a 3D-SSP template.Results: Mean Az for visual interpretation of SPECT alone (0.679 ± 0.058) was significantly smaller than that for visual interpretation of both SPECT and 3D-SSP (0.778 ± 0.060). Az for the automated diagnosis (0.883 ± 0.037) was significantly greater than that for both modes of visual interpretation.Conclusions: 3D-SSP enhanced performance of the nuclear medicine physicians inspecting SPECT. Performance of the automated diagnosis exceeded that of the physicians inspecting SPECT with and without 3D-SSP.
DOI：
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发表时间：
1995-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
S. Minoshima;K. Frey;K. Frey;R. Koeppe;N. Foster;David E. Kuhl
通讯作者：
S. Minoshima;K. Frey;K. Frey;R. Koeppe;N. Foster;David E. Kuhl
解剖标准化：功能性大脑图像的线性缩放和非线性变形。
DOI：
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发表时间：
1994
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Minoshima,S;Koeppe,RA;Frey,KA;Kuhl,DE
通讯作者：
Kuhl,DE