Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
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DOI：
10.1038/ng888
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发表时间：
2002-06-01
期刊：
影响因子：
30.8
通讯作者：
Powers, S
中科院分区：
文献类型：
--
作者：
Li, J;Yang, Y;Powers, S
我们发现，PPM 1D，编码丝氨酸/苏氨酸蛋白磷酸酶，位于在乳腺癌中扩增的17 q23区域的中心。我们发现，该基因的过度表达赋予两个致癌表型的细胞培养：血清饥饿和原代细胞与RAS合作的转化诱导的细胞凋亡的衰减。
We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.