Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO)
Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO)
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DOI：
10.1007/s10544-018-0335-z
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发表时间：
2018-10-05
影响因子：
2.8
通讯作者：
Roy, Shuvo
中科院分区：
文献类型：
--
作者：
Abada, Emily N.;Feinberg, Benjamin J.;Roy, Shuvo
虽然体外膜氧合（ECMO）对肺或心力衰竭患者是一种有价值的治疗方法，但由于促凝中空纤维膜几何形状的血液相容性问题，ECMO的临床应用仍然有限。之前，我们证明了硅纳米孔（SNM）和微孔（SM）膜在血液接触装置中两个液相间运输的可行性。在此，我们研究了SNM和SM膜的不同孔径-单独或带有聚二甲基硅氧烷（PDMS）保护涂层-确定气体交换适用性的参数。我们描述了这些膜的气泡或破裂点，以确定气体栓塞形成的扫气压力。最小孔径的SNM和涂有PDMS涂层的SM可承受超过260 cmHg的压力而不破裂，与中空纤维扫气压力相当。带PDMS和不带PDMS的SM的氧通量分别为0.0306 +/- 0.0028和0.0297 +/- 0.0012mL/min，差异不显著，而SNM的氧通量显著低于0.0149 +/- 0.0040mL/min。然而，SNM的面积归一化传质系数为338 +/- 54mL O-2 m(-2)min(-1) cmHg(-1)，比有和没有PDMS的SM(57.3 +/- 5.5和55.6 +/- 2.2mL O-2 m(-2)min（-1) cmHg(-1)）高一个数量级。最后，我们得出结论，SM-PDMS可能是ECMO的有效膜，因为它们具有机械坚固性和高氧通量的能力。
While extracorporeal membrane oxygenation (ECMO) is a valuable therapy for patients with lung or heart failure, clinical use of ECMO remains limited due to hemocompatibility concerns with pro-coagulatory hollow fiber membrane geometries. Previously, we demonstrated the feasibility of silicon nanopore (SNM) and micropore (SM) membranes for transport between two liquid-phase compartments in blood-contacting devices. Herein, we investigate various pore sizes of SNM and SM membranes - alone or with a polydimethylsiloxane (PDMS) protective coating - for parameters that determine suitability for gas exchange. We characterized the bubble or rupture point of these membranes to determine sweep gas pressures at which gas emboli would form. The smallest pore size SNM and the SM with PDMS coating could be pressurized in excess of 260 cmHg without rupture, which is comparable to hollow fiber sweep gas pressures. Oxygen flux for the SM with and without PDMS was insignificantly different at 0.0306 +/- 0.0028 and 0.0297 +/- 0.0012mL/min, respectively, while SNM flux was significantly lower at 0.0149 +/- 0.0040mL/min. However, the area-normalized mass transfer coefficient of the SNM was 338 +/- 54mL O-2 m(-2)min(-1) cmHg(-1) - an order of magnitude higher than that of the SM with and without PDMS (57.3 +/- 5.5 and 55.6 +/- 2.2mL O-2 m(-2)min(-1) cmHg(-1)). Ultimately, we conclude that SM-PDMS may make effective membranes for ECMO, since they are both mechanically robust and capable of high oxygen flux.