Evidence for Mediodorsal Thalamus and Prefrontal Cortex Interactions during Cognition in Macaques
Evidence for Mediodorsal Thalamus and Prefrontal Cortex Interactions during Cognition in Macaques
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DOI：
10.1093/cercor/bhv093
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发表时间：
2015-11-01
期刊：
影响因子：
3.7
通讯作者：
Mitchell, Anna S.
中科院分区：
文献类型：
--
作者：
Browning, Philip G. F.;Chakraborty, Subhojit;Mitchell, Anna S.
有人提出，内侧背丘脑通过与前额叶皮层的相互作用来促进认知。然而，有相对较少的证据，详细说明之间的相互作用，内侧背丘脑和前额叶皮层与认知灵长类动物。本研究采用分离损伤的方法研究了恒河猴在学习、记忆和决策任务中的这些相互作用。在手术前，猴子学会了嵌入在彩色视觉背景中的就地对象场景辨别。单侧神经毒性病变的大细胞内侧背丘脑（MDMC）受损的能力，学习新的对象在现场的场景歧视。相反，单侧腹外侧和眶前额叶皮层消融（PFv+o）保持学习完整。第二个单侧MDmc或PFv+o病变在对侧半球的第一个操作，造成功能MDmc-PFv+o断开跨半球，进一步损害学习对象在现场场景的歧视，但对象歧视学习保持完整。满足性贬值后的适应性决策也减少了。这些数据突出了MDmc和PFv+o之间的相互作用的功能重要性，在学习对象在现场的场景歧视和自适应决策，但不是对象歧视学习。此外，单侧去除MDmc后观察到的学习缺陷，而不是PFv+o提供了直接的行为证据，MDmc的作用影响更广泛的额叶区域的认知。
It is proposed that mediodorsal thalamus contributes to cognition via interactions with prefrontal cortex. However, there is relatively little evidence detailing the interactions between mediodorsal thalamus and prefrontal cortex linked to cognition in primates. This study investigated these interactions during learning, memory, and decision-making tasks in rhesus monkeys using a disconnection lesion approach. Preoperatively, monkeys learned object-in-place scene discriminations embedded within colorful visual backgrounds. Unilateral neurotoxic lesions to magnocellular mediodorsal thalamus (MDmc) impaired the ability to learn new object-in-place scene discriminations. In contrast, unilateral ablations to ventrolateral and orbital prefrontal cortex (PFv+o) left learning intact. A second unilateral MDmc or PFv+o lesion in the contralateral hemisphere to the first operation, causing functional MDmc-PFv+o disconnection across hemispheres, further impaired learning object-in-place scene discriminations, although object discrimination learning remained intact. Adaptive decision-making after reward satiety devaluation was also reduced. These data highlight the functional importance of interactions between MDmc and PFv+o during learning object-in-place scene discriminations and adaptive decision-making but not object discrimination learning. Moreover, learning deficits observed after unilateral removal of MDmc but not PFv+o provide direct behavioral evidence of the MDmc role influencing more widespread regions of the frontal lobes in cognition.