2',3'-Dideoxyinosine-induced Mallory bodies in patients with HIV.
2',3'-Dideoxyinosine-induced Mallory bodies in patients with HIV.
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HIV 患者中 2,3-双脱氧肌苷诱导的马洛里体。
DOI：
10.1093/ajcp/108.3.280
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发表时间：
1997
影响因子：
3.5
通讯作者：
French,SW
中科院分区：
文献类型：
--
作者：
Hu,B;French,SW
Didanosine (ddI) that inhibits the reverse transcriptase of human immunodeficiency virus (HIV) causes steatosis and fulminant hepatitis in some patients with HIV. We studied hepatic histopathologic changes with particular attention to ddl-induced Mallory body formation. Three liver biopsies were performed on three patients with HIV who were treated with ddl; an autopsy was performed on a patient with HIV who was also treated with ddl. All hepatic specimens were studied with a routine liver immunohistochemical panel including antibodies to ubiquitin and cytokeratin (CAM 5.2). Morphologically, all hepatic specimens showed focal to diffuse steatosis with a predominance of macrovesicular fatty change. Fibrosis was minimal in three cases. No secondary bacterial and fungal infections were noted. Single or clusters of “empty cells” were present, and some contained Mallory bodies validated by ubiquitin stain. Empty cells are hepatocytes that fail to stain positive for cytokeratin. The Mallory bodies were different from the others because they were randomly distributed and occurred in noncirrhotic hepatic tissue. In the autopsy specimen, the Mallory bodies had a centrilobular location with central fibrosis (central sclerosing hyaline necrosis).
