In-silico analysis of myeloid cells across the animal kingdom reveals neutrophil evolution by colony-stimulating factors.
In-silico analysis of myeloid cells across the animal kingdom reveals neutrophil evolution by colony-stimulating factors.
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DOI：
10.7554/elife.60214
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发表时间：
2020-11-25
期刊：
影响因子：
7.7
通讯作者：
Woollard KJ
中科院分区：
文献类型：
--
作者：
Pinheiro D;Mawhin MA;Prendecki M;Woollard KJ
中性粒细胞构成哺乳动物血液中最大的吞噬性粒细胞群体。中性粒细胞和单核细胞的发育和功能主要分别由粒细胞集落刺激因子受体家族（CSF 3R/CSF 3）和巨噬细胞集落刺激因子受体家族（CSF 1 R/IL 34/CSF 1）控制。本研究使用各种技术，考虑了受体：配体配对的出现如何塑造血髓细胞群的分布。比较基因分析支持CSF 1 R/IL 34和CSF 3R/CSF 3的祖先配对，以及在有颌/无颌鱼出现后，CSF 1在谱系中出现。进一步的分析表明，CSF 3的出现导致了两栖动物和早期爬行动物之间粒细胞分布的重组。然而，内温动物的出现可能导致了中性粒细胞/嗜异性细胞在现代哺乳动物和鸟类中的主导地位。总之，我们发现CSF 3R/CSF 3的出现是现代哺乳动物中性粒细胞随后进化的关键因素。
Neutrophils constitute the largest population of phagocytic granulocytes in the blood of mammals. The development and function of neutrophils and monocytes is primarily governed by the granulocyte colony-stimulating factor receptor family (CSF3R/CSF3) and macrophage colony-stimulating factor receptor family (CSF1R/IL34/CSF1) respectively. Using various techniques this study considered how the emergence of receptor:ligand pairings shaped the distribution of blood myeloid cell populations. Comparative gene analysis supported the ancestral pairings of CSF1R/IL34 and CSF3R/CSF3, and the emergence of CSF1 later in lineages after the advent of Jawed/Jawless fish. Further analysis suggested that the emergence of CSF3 lead to reorganisation of granulocyte distribution between amphibian and early reptiles. However, the advent of endothermy likely contributed to the dominance of the neutrophil/heterophil in modern-day mammals and birds. In summary, we show that the emergence of CSF3R/CSF3 was a key factor in the subsequent evolution of the modern-day mammalian neutrophil.