Topography and timing of activity in right inferior frontal cortex and anterior insula for stopping movement
Topography and timing of activity in right inferior frontal cortex and anterior insula for stopping movement
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DOI：
10.1002/hbm.23835
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发表时间：
2018-01-01
影响因子：
4.8
通讯作者：
Tandon, Nitin
中科院分区：
文献类型：
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作者：
Bartoli, Eleonora;Aron, Adam R.;Tandon, Nitin
停止初始动作会激活右下额皮质 (rIFC) 和前岛叶 (rAI)。关于它们是否包含单一皮质簇 rIFC/rAI 或 rIFC 是否是主要停止位点存在争议。为了解决这个问题，我们直接从这些结构进行记录，同时利用紧密间隔的立体脑电图 (SEEG) 电极的高时空分辨率。我们研究了 12 名执行停止信号任务的患者。在每次试验中，他们都会启动运动反应（Go），并尝试在偶尔出现停止信号时停下来。无论停止是否成功，rIFC 和 rAI 在停止信号后和停止时间内（停止信号反应时间，SSRT）均表现出宽带伽马活性（BGA）增加。 rIFC 中出现这种反应的电极比例明显高于 rAI。此外，rIFC 响应先于 rAI 响应。最后，虽然 rIFC 中的 BGA 增加主要发生在 SSRT 之前，但 rAI 在 SSRT 后显示出 β 和低伽马带的持续增加。总之，rIFC 在停止信号发出后不久就被激活，先于 rAI 并且比 rAI 更强烈，而 rAI 在停止信号开始后表现出更长时间的反应。我们的结果与这样的观点最相符：rIFC 参与与更广泛的网络协同触发彻底停止，而 rAI 可能涉及其他过程，例如唤醒、显着性或行为调整。 Hum Brain Mapp 39:189-203, 2018。(c) 2017 Wiley periodicals, Inc.
Stopping incipient action activates both the right inferior frontal cortex (rIFC) and the anterior insula (rAI). Controversy has arisen as to whether these comprise a unitary cortical clusterthe rIFC/rAIor whether rIFC is the primary stopping locus. To address this, we recorded directly from these structures while taking advantage of the high spatiotemporal resolution of closely spaced stereo-electro-encephalographic (SEEG) electrodes. We studied 12 patients performing a stop-signal task. On each trial they initiated a motor response (Go) and tried to stop to an occasional stop signal. Both the rIFC and rAI exhibited an increase in broadband gamma activity (BGA) after the stop signal and within the time of stopping (stop signal reaction time, SSRT), regardless of the success of stopping. The proportion of electrodes with this response was significantly greater in the rIFC than the rAI. Also, the rIFC response preceded that in the rAI. Last, while the BGA increase in rIFC occurred mainly prior to SSRT, the rAI showed a sustained increase in the beta and low gamma bands after the SSRT. In summary, the rIFC was activated soon after the stop signal, prior to and more robustly than the rAI, which on the other hand, showed a more prolonged response after the onset of stopping. Our results are most compatible with the notion that the rIFC is involved in triggering outright stopping in concert with a wider network, while the rAI is likely engaged by other processes, such as arousal, saliency, or behavioral adjustments. Hum Brain Mapp 39:189-203, 2018. (c) 2017 Wiley Periodicals, Inc.