Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.
Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.
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DOI：
10.1016/j.devcel.2015.02.001
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发表时间：
2015-05
影响因子：
11.8
通讯作者：
Jingjing Xia;J. Swiercz;I. Bañón-Rodríguez;I. Matković;Giuseppina Federico;Tianliang Sun;T. Franz;C. Brakebusch;A. Kumanogoh;R. Friedel;F. Martín-Belmonte;H. Gröne;S. Offermanns;T. Worzfeld
中科院分区：
文献类型：
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作者：
Jingjing Xia;J. Swiercz;I. Bañón-Rodríguez;I. Matković;Giuseppina Federico;Tianliang Sun;T. Franz;C. Brakebusch;A. Kumanogoh;R. Friedel;F. Martín-Belmonte;H. Gröne;S. Offermanns;T. Worzfeld
Morphogenesis, homeostasis, and regeneration of epithelial tissues rely on the accurate orientation of cell divisions, which is specified by the mitotic spindle axis. To remain in the epithelial plane, symmetrically dividing epithelial cells align their mitotic spindle axis with the plane. Here, we show that this alignment depends on epithelial cell-cell communication via semaphorin-plexin signaling. During kidney morphogenesis and repair, renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic spindle, leading to severe defects in epithelial architecture and function. Analyses of a series of transgenic and knockout mice indicate that Plexin-B2 controls the cell division axis by signaling through its GTPase-activating protein (GAP) domain and Cdc42. Our data uncover semaphorin-plexin signaling as a central regulatory mechanism of mitotic spindle orientation necessary for the alignment of epithelial cell divisions with the epithelial plane.
