Indicators of Buprenorphine and Methadone Use and Abuse: What Do We Know?
Indicators of Buprenorphine and Methadone Use and Abuse: What Do We Know?
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DOI：
10.1111/j.1521-0391.2009.00008.x
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发表时间：
2010-01-01
影响因子：
3.7
通讯作者：
McCance-Katz, Elinore F.
中科院分区：
文献类型：
--
作者：
Maxwell, Jane Carlisle;McCance-Katz, Elinore F.
处方阿片类药物的滥用是一个日益严重的问题。现在分发的美沙酮止痛药的数量超过了阿片类药物治疗中使用的液体美沙酮，丁丙诺啡指标的增加证明需要监测和干预以减少这种药物的滥用。讨论了需要额外和改进的数据来跟踪趋势，以及有关使用者特征和药物组合的发现。介绍了与美沙酮或丁丙诺啡相关的毒性数据，特别是与其他处方药联合使用时的毒性数据，并提供了临床意义和注意事项。这些发现强调医生需要意识到潜在的毒性并就这些问题对患者进行教育。 （Am J Addict 2009；19：73-88）。
Abuse of prescription opioids is a growing problem. The number of methadone pain pills distributed now exceeds liquid methadone used in opioid treatment, and the increases in buprenorphine indicators provide evidence of the need to monitor and intervene to decrease the abuse of this drug. The need for additional and improved data to track trends is discussed, along with findings as to the characteristics of the users and combinations of drugs. Data on toxicities related to methadone or buprenorphine, particularly in combination with other prescribed drugs, are presented and clinical implications and considerations are offered. These findings underscore the need for physicians to be aware of potential toxicities and to educate their patients regarding these issues. (Am J Addict 2009;19:73-88).