Saccadic eye movement abnormalities in relatives of patients with schizophrenia.
Saccadic eye movement abnormalities in relatives of patients with schizophrenia.
复制标题
精神分裂症患者亲属的眼球扫视运动异常。
DOI：
10.1016/s0920-9964(99)00193-0
复制
发表时间：
2000
影响因子：
4.5
通讯作者：
Sherr,J
中科院分区：
文献类型：
--
作者：
Thaker,GK;Ross,DE;Cassady,SL;Adami,HM;Medoff,DR;Sherr,J
最近的研究注意到精神分裂症患者亲属的跳眼运动异常。目前的研究检查了跳眼系统的哪些方面受到影响，这些跳眼异常是否与精神分裂症谱系人格症状（SSP）相关，以及这种关联是否依赖于精神分裂症家族史。此外，该研究还检查了亲属中有多少比例的人患有跳眼异常。55名没有DSM-III-R轴I诊断的一级亲属参加了研究。这些亲属中有21人出现SSP症状，34人没有II轴诊断。从社区招募了62名没有轴I诊断的受试者。25人有SSP症状，37人没有II轴诊断。观察前扫视（向目标方向扫视）和反扫视（与目标跳跃方向相反的扫视）。亲属，特别是那些患有SSP的人，在执行反扫视任务时遇到困难，这表明错误率更高，反扫视延迟时间更长。虽然两组在某些指标上田的影响有所不同，但在亲属和社区受试者中，田的影响没有差异。与14.9%的所有亲属（35.3%的SSP亲属和3.3%的非SSP亲属）相比，只有一小部分社区受试者（1.6%）的抗扫视潜伏期“异常”。精神分裂症患者的亲属在涉及产生内部驱动的扫视和抑制不必要的扫视的跳眼系统方面存在缺陷。这些缺陷涉及额叶皮层和基底神经节区域的眼运动神经元回路。这些缺陷与SSP症状有关，但与精神分裂症没有血缘关系。高危人群中相对较高的异常发生率可能与在连锁分析中使用这些措施有关。
Recent studies note abnormalities in saccadic eye movements of relatives of patients with schizophrenia. The current study examined which aspects of the saccadic system are affected, whether these saccadic abnormalities are associated with schizophrenia spectrum personality symptoms (SSP), and whether such an association is dependent on a family history of schizophrenia. Furthermore, the study examined what proportion of relatives have the saccadic abnormality(ies). Fifty-five first-degree relatives with no DSM-III-R Axis I diagnosis participated in the study. Twenty-one of these relatives experienced SSP symptoms and 34 had no Axis II diagnosis. Sixty-two subjects with no Axis I diagnosis were recruited from the community. Twenty-five experienced SSP symptoms and 37 had no Axis II diagnosis. Prosaccades (saccades toward the target) and antisaccades (saccades made in the opposite direction of the target jump) were examined. Relatives, particularly those with SSP, had difficulties with the antisaccade task as suggested by higher error rates and longer antisaccade latency. Prosaccades were not different in relatives compared to the community subjects, although the effects of field were different in the two groups on some measures. The antisaccade latency was ‘abnormal’ in only a small proportion (1.6%) of community subjects compared to 14.9% of all relatives (35.3% of SSP relatives and 3.3% of non-SSP relatives). Relatives of patients with schizophrenia have deficits in aspects of the saccadic system involved in generating internally driven saccades and inhibition of unwanted saccades. These deficits implicate frontal ocular motor neuronal circuitry involving frontal cortical and basal ganglia areas. These deficits are associated with SSP symptoms, but not in the absence of a blood relationship to schizophrenia. The relatively high prevalence rate of the abnormality in at-risk subjects may have relevance for use of these measures in linkage analysis.