Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method
Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method
复制标题
DOI：
10.1529/biophysj.103.035840
复制
发表时间：
2004-09-01
影响因子：
3.4
通讯作者：
Hisada, T
中科院分区：
文献类型：
--
作者：
Watanabe, H;Sugiura, S;Hisada, T
为了将亚细胞分子事件与心脏的器官水平生理联系起来，我们开发了一个基于三维有限元的模拟程序，该程序结合了兴奋-收缩耦合及其传播的细胞机制，并模拟了人体左心室收缩和舒张过程中的流体-结构相互作用。细胞模型采用FitzHugh-Nagumo模型和四态模型。心室壁和腔内血液均采用有限元网格模拟。针对大区域变化问题，提出了一种具有自动网格更新的任意拉格朗日欧拉有限元方法，并采取了强耦合策略。使用肺循环和左心房的电模拟作为前负荷，并使用Windkessel模型作为后负荷，模拟心室充盈和射血的动力学。我们成功地再现了由早期快速充盈和心房收缩组成的双相充盈流，与临床观察中报道的相似。此外，流体结构分析使我们能够分析波的传播速度的填充流。这个模拟器可以是一个强大的工具，建立分子异常之间的联系，在宏观水平上的临床疾病。
To relate the subcellular molecular events to organ level physiology in heart, we have developed a three-dimensional finite-element-based simulation program incorporating the cellular mechanisms of excitation-contraction coupling and its propagation, and simulated the fluid-structure interaction involved in the contraction and relaxation of the human left ventricle. The FitzHugh-Nagumo model and four-state model representing the cross-bridge kinetics were adopted for cellular model. Both ventricular wall and blood in the cavity were modeled by finite element mesh. An arbitrary Lagrangian Eulerian finite element method with automatic mesh updating has been formulated for large domain changes, and a strong coupling strategy has been taken. Using electrical analog of pulmonary circulation and left atrium as a preload and the windkessel model as an afterload, dynamics of ventricular filling as well as ejection was simulated. We successfully reproduced the biphasic filling flow consisting of early rapid filling and atrial contraction similar to that reported in clinical observation. Furthermore, fluid-structure analysis enabled us to analyze the wave propagation velocity of filling flow. This simulator can be a powerful tool for establishing a link between molecular abnormality and the clinical disorder at the macroscopic level.