Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers.
Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers.
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DOI：
10.1364/boe.3.002733
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发表时间：
2012-11-01
影响因子：
3.4
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
--
作者：
Grulkowski I;Liu JJ;Potsaid B;Jayaraman V;Lu CD;Jiang J;Cable AE;Duker JS;Fujimoto JG
我们展示了利用垂直腔表面发射激光 (VCSEL) 技术进行扫频源 OCT，用于体内高速视网膜、眼前节和全眼成像。 MEMS 可调谐 VCSEL 可实现长相干长度、可调节光谱扫描范围和可调节高扫描速率（50-580 kHz 轴向扫描速率）。这些功能可以将多种眼科应用集成到一台仪器中。该设备的操作模式包括：超高速、高分辨率视网膜成像（高达 580 kHz）；高速、长深度范围眼前节成像 (100 kHz) 和超长范围全眼成像 (50 kHz)。高速成像可实现宽视场视网膜扫描，而 1060 nm 的光穿透力增强可实现脉络膜脉管系统的可视化。还显示了从角膜到晶状体后表面的眼前节的综合体积数据集。可调节的 VCSEL 扫描范围和速率使其能够实现约 50 mm 的超长成像深度范围，并首次展示了跨越整个眼睛的体内 3D OCT 成像，用于非接触式测量眼内距离（包括眼轴长度）。采用 VCSEL 技术的扫描源 OCT 对于下一代集成眼科 OCT 仪器可能很有吸引力。
We demonstrate swept source OCT utilizing vertical-cavity surface emitting laser (VCSEL) technology for in vivo high speed retinal, anterior segment and full eye imaging. The MEMS tunable VCSEL enables long coherence length, adjustable spectral sweep range and adjustable high sweeping rate (50–580 kHz axial scan rate). These features enable integration of multiple ophthalmic applications into one instrument. The operating modes of the device include: ultrahigh speed, high resolution retinal imaging (up to 580 kHz); high speed, long depth range anterior segment imaging (100 kHz) and ultralong range full eye imaging (50 kHz). High speed imaging enables wide-field retinal scanning, while increased light penetration at 1060 nm enables visualization of choroidal vasculature. Comprehensive volumetric data sets of the anterior segment from the cornea to posterior crystalline lens surface are also shown. The adjustable VCSEL sweep range and rate make it possible to achieve an extremely long imaging depth range of ~50 mm, and to demonstrate the first in vivo 3D OCT imaging spanning the entire eye for non-contact measurement of intraocular distances including axial eye length. Swept source OCT with VCSEL technology may be attractive for next generation integrated ophthalmic OCT instruments.