PERCEPTION OF SPECIFIC TRIGEMINAL CHEMOSENSORY AGONISTS
PERCEPTION OF SPECIFIC TRIGEMINAL CHEMOSENSORY AGONISTS
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DOI：
10.1016/j.neuroscience.2011.04.065
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发表时间：
2011-08-25
期刊：
影响因子：
3.3
通讯作者：
Lundstrom, J. N.
中科院分区：
文献类型：
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作者：
Frasnelli, J.;Albrecht, J.;Lundstrom, J. N.
鼻内三叉神经系统是除嗅觉和味觉之外的第三种化学感觉。与嗅觉和味觉相反，我们仍然缺乏对三叉神经系统受体结合和感知之间关系的了解。因此，我们通过评估受试者识别单鼻刺激设计中哪个鼻孔受到刺激的能力，研究了鼻内三叉神经系统对三叉神经受体TRPM8和TRPA1激动剂的敏感性。我们对正确识别的数量进行了总结，得出偏侧化分数。刺激物是薄荷醇（激活TRPM8受体）、桉油精（TRPM8）、芥末油（TRPA1）及其两种混合物（薄荷醇/桉油精和薄荷醇/芥末油）。此外，我们检查了强度和偏侧化分数之间的关系，并研究了混合物的强度评估和偏侧化分数是否表现出相加效应。所有刺激都被正确偏侧化，显着高于偶然性。在受试者中，激活相同受体的单一化合物的侧化评分显示出比激活不同受体的刺激更强的相关性。尽管单一化合物是等强度的，但薄荷醇和桉树油的混合物（仅激活TRPM8）被认为比薄荷醇和芥末油的混合物（激活TRPM8和TRPA1）更弱并且侧化精度较低，这表明前一种混合物具有抑制作用。总之，三叉神经感觉神经元不同亚群的敏感性似乎相关，但只是在一定程度上相关。各种鼻内三叉神经刺激之间的敏感性具有很大的一致性，这表明测量对一种单一三叉神经化学刺激的敏感性可能足以总体评估三叉神经系统的化学敏感性。此外，对于激活相同受体的刺激，似乎会发生与其他化学感应系统中观察到的类似的混合抑制效应。 (C) 2011 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
The intranasal trigeminal system is a third chemical sense in addition to olfaction and gustation. As opposed to smell and taste, we still lack knowledge on the relationship between receptor binding and perception for the trigeminal system. We therefore investigated the sensitivity of the intranasal trigeminal system towards agonists of the trigeminal receptors TRPM8 and TRPA1 by assessing subjects' ability to identify which nostril has been stimulated in a monorhinal stimulation design. We summed the number of correct identifications resulting in a lateralization score. Stimuli were menthol (activating TRPM8 receptors), eucalyptol (TRPM8), mustard oil (TRPA1) and two mixtures thereof (menthol/eucalyptol and menthol/mustard oil). In addition, we examined the relationship between intensity and lateralization scores and investigated whether intensity evaluation and lateralization scores of the mixtures show additive effects. All stimuli were correctly lateralized significantly above chance. Across subjects the lateralization scores for single compounds activating the same receptor showed a stronger correlation than stimuli activating different receptors. Although single compounds were isointense, the mixture of menthol and eucalyptol (activating only TRPM8) was perceived as weaker and was lateralized less accurately than the mixture of menthol and mustard oil (activating both TRPM8 and TRPA1) suggesting suppression effects in the former mixture. In conclusion, sensitivity of different subpopulations of trigeminal sensory neurons seems to be related, but only to a certain degree. The large coherence in sensitivity between various intranasal trigeminal stimuli suggests that measuring sensitivity to one single trigeminal chemical stimulus may be sufficient to generally assess the trigeminal system's chemosensitivity. Further, for stimuli activating the same receptor a mixture suppression effect appears to occur similar to that observed in the other chemosensory systems. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.