Prevalence of chronic respiratory disease in urban and rural Uganda
Prevalence of chronic respiratory disease in urban and rural Uganda
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DOI：
10.2471/blt.18.216523
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发表时间：
2019-05-01
影响因子：
11.1
通讯作者：
Checkley, William
中科院分区：
文献类型：
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作者：
Siddharthan, Trishul;Grigsby, Matthew;Checkley, William
目的了解乌干达城市和农村慢性呼吸道疾病的患病率及其危险因素。方法以人群为基础的横断面研究包括35岁以上的成年人。所有参与者都根据标准指南进行了肺活量测定，并完成了关于呼吸道症状、功能状态和人口统计特征的问卷调查。监测了四种慢性呼吸系统疾病的存在：慢性阻塞性肺疾病(COPD)、哮喘、慢性支气管炎和限制性肺活量测定模式。总共发现，1502名参与者(平均年龄：46.9岁)具有可接受的、可重复性的肺活量测定结果：Nakaseke农村837人(56%)，城市坎帕拉665人(44%)。总体而言，46.5%(698/1502)为男性。年龄调整后的任何慢性呼吸系统疾病患病率为20.2%。年龄调整后的慢性阻塞性肺病在农村的患病率显著高于城市参与者(分别为6.1%和1.5%；P<；0.001)，而哮喘在城市参与者中的患病率明显更高：9.7%对4.4%(P<；0.001)。慢性支气管炎的年龄调整患病率在农村和城市参与者中相似(分别为3.5%和2.2%；P=0.62)，也与限制性肺活量测定模式相似(10.9%和9.4%；P=0.82)。农村居民、吸烟、体重指数和肺结核的人群归因危险度分别为51.5%、19.5%、16.0%、18.5 kg/m(2)和13.0%。结论乌干达农村和城市慢性呼吸道疾病患病率较高。居住地是COPD和哮喘最重要的危险因素。
Objective To determine the prevalence of chronic respiratory diseases in urban and rural Uganda and to identify risk factors for these diseases.Methods The population-based, cross-sectional study included adults aged 35 years or older. All participants were evaluated by spirometry according to standard guidelines and completed questionnaires on respiratory symptoms, functional status and demographic characteristics. The presence of four chronic respiratory conditions was monitored: chronic obstructive pulmonary disease (COPD), asthma, chronic bronchitis and a restrictive spirometry pattern.Findings In total, 1502 participants (average age: 46.9 years) had acceptable, reproducible spirometry results: 837 (56%) in rural Nakaseke and 665 (44%) in urban Kampala. Overall, 46.5% (698/1502) were male. The age-adjusted prevalence of any chronic respiratory condition was 20.2%. The age-adjusted prevalence of COPD was significantly greater in rural than urban participants (6.1 versus 1.5%, respectively; P < 0.001), whereas asthma was significantly more prevalent in urban participants: 9.7% versus 4.4% in rural participants (P < 0.001). The age-adjusted prevalence of chronic bronchitis was similar in rural and urban participants (3.5 versus 2.2%, respectively; P = 0.62), as was that of a restrictive spirometry pattern (10.9 versus 9.4%; P = 0.82). For COPD, the population attributable risk was 51.5% for rural residence, 19.5% for tobacco smoking, 16.0% for a body mass index < 18.5 kg/m(2) and 13.0% for a history of treatment for pulmonary tuberculosis.Conclusion The prevalence of chronic respiratory disease was high in both rural and urban Uganda. Place of residence was the most important risk factor for COPD and asthma.