Hygroscopicity and the water-polymer interaction parameter of nano-sized biodegradable hydrophilic substances
Hygroscopicity and the water-polymer interaction parameter of nano-sized biodegradable hydrophilic substances
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DOI：
10.1080/02786826.2021.1931012
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发表时间：
2021-06
影响因子：
5.2
通讯作者：
Chunxia Mao;K. Malek;A. Asa-Awuku
中科院分区：
文献类型：
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作者：
Chunxia Mao;K. Malek;A. Asa-Awuku
摘要吸湿性是纳米粒子科学和工程中最重要的物理化学性质之一。吸湿性决定了颗粒在水蒸气存在时膨胀或收缩的能力。有机气溶胶的吸湿性是溶质摩尔体积的已知函数。对于用于药物输送的低分子量(<；200gmol−1)有机化合物尤其如此。在这项工作中，用一种快速而独特的吸湿性-云凝聚核激活技术测量了甘露醇、乳糖、明胶和聚乙二醇这四种常用的可生物降解亲水性化合物。用Flory-Huggins Köhler理论估算了单参数吸湿性。结果表明，对于高相对分子质量的化合物，还必须考虑水-聚合物相互作用参数，在过饱和区可以确定纳米粒子的水-聚合物相互作用参数。水的亲和力对纳米粒子的吸湿性至关重要，随着分子量的增加，有机摩尔体积贡献开始减小。此外，我们还为聚合物的吸湿性提供了一种新的依赖于尺寸的参数。综上所述，水的亲和力的相互作用参数可以测量的纳米颗粒，并发挥重要作用的吸水率的有机纳米颗粒。版权所有©2021美国气溶胶研究协会
Abstract Hygroscopicity is one of the most important physicochemical properties for nanoparticle science and engineering. Hygroscopicity determines the ability of a particle to swell or contract in the presence of water vapor. The hygroscopicity for organic aerosol is a known function of the solute molar volume. This is particularly true for low-molecular weight (<200 g mol−1) organic compounds used for drug delivery. In this work, four commonly used biodegradable hydrophilic compounds, mannitol, lactose, gelatin and polyethylene glycol are measured with a fast and unique hygroscopicity-cloud condensation nuclei activation technique. Flory-Huggins Köhler theory is used to estimate the single parameter hygroscopicity. Results show that for the high molecular weight compounds, a water-polymer interaction parameter must also be considered and the water-polymer interaction parameter for nanoparticles can be determined in the supersaturated regime. The water affinity becomes essential to nanoparticle hygroscopicity, and the organic molar volume contribution starts to decrease as the molecular weight increases. Furthermore, we provide a new size-dependent parameterization for hygroscopicity of polymers. In summary, the water affinity of the interaction parameter can be measured for nano-particles and plays an important role of the water uptake of organic nano-particles. Copyright © 2021 American Association for Aerosol Research