Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid
Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid
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DOI：
10.1016/j.poly.2018.08.026
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发表时间：
2018-11-15
期刊：
影响因子：
2.6
通讯作者：
Gulcin, Ilhami
中科院分区：
文献类型：
--
作者：
Huseynova, Mansura;Taslimi, Parham;Gulcin, Ilhami
硝酸钴和硝酸镍与乙醛酸缩氨基硫脲（H（2）GAT）形成经验组成为Co（C3 H4 N3 O2 S）（2）中心点2 H（2）O、Ni（C3 H4 N3 O2 S）（2）中心点2 H（2）O和Ni（C3 H6 N3 O2 S）（2）的配合物。X-射线衍射研究表明，Co（HGAT）（2）中心点2 H（2）O、Ni（HGAT）（2）中心点2 H（2）O配合物为单核结构，其中金属周围的配位为八面体，由两个硫原子、两个氮原子和两个氧原子组成。以NiCl_2为中心点，H_2O与2-[2-（氨硫代甲基）肼基]乙酸（H（2）TAA）反应，合成了一种含氢化偶氮甲亚胺配体的氨基硫脲金属配合物。这些化合物的氧化还原性能也进行了研究，通过在二甲基亚砜/四丁基高氯酸铵铂伏安法。这些乙醛酸缩氨基硫脲衍生物对α-糖苷酶、胞浆碳酸酐酶I和II同工酶、丁酰胆碱酯酶和乙酰胆碱酯酶具有有效的抑制作用。发现对于hCA I，Ki值为26.12-36.58 nM，对于hCA II，Ki值为20.73-40.78 nM，对于AChE，Ki值为184.30-642.18 nM，对于BChE，Ki值为123.67-342.37 nM，对于α-糖苷酶，Ki值为14.66-45.62 nM。(C)2018爱思唯尔有限公司版权所有
Cobalt and nickel nitrates form with thiosemicarbazone of glyoxylic acid (H(2)GAT) complexes of empirical composition Co(C3H4N3O2S)(2)center dot 2H(2)O, Ni(C3H4N3O2S)(2)center dot 2H(2)O and Ni(C3H6N3O2S)(2). X-ray diffraction studies have shown that the Co(HGAT)(2)center dot 2H(2)O, Ni(HGAT)(2)center dot 2H(2)O complexes are mononuclear, in which the coordination around the metal is octahedral, made up of two sulfur atoms, two nitrogen atoms and two oxygen atoms from two ligands. By the interaction of NiCl2 center dot H2O with 2-[2-(aminothioxomethyl)hydrazinyl] acetic acid (H(2)TAA) instead of the expected the metal thiosemicarbazonate complex with the hydrogenated on the azomethine group ligand was obtained. The redox properties of these compounds were also investigated by voltammetry on Pt in dimethylsulfoxide/tetrabutylammonium perchlorate. These thiosemicarbazone of glyoxylic acid derivatives had effective inhibition against alpha-glycosidase, cytosolic carbonic anhydrase I and II isoenzymes, butyrylcholinesterase and acetylcholinesterase. K-i values were found as 26.12-36.58 nM for hCA I, 20.73-40.78 nM for hCA II, 184.30-642.18 nM for AChE, 123.67-342.37 nM for BChE, and 14.66-45.62 nM for alpha-glycosidase. (C) 2018 Elsevier Ltd. All rights reserved.