Sperm RNA-mediated epigenetic inheritance in mammals: challenges and opportunities.
Sperm RNA-mediated epigenetic inheritance in mammals: challenges and opportunities.
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DOI：
10.1071/rd22218
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发表时间：
2022-12
影响因子：
1.9
通讯作者：
Chen, Qi
中科院分区：
文献类型：
--
作者：
Chen, Qi
关键词：
新出现的证据表明，除了传递单倍体DNA外，哺乳动物精子还携带各种类型的rna，这些rna对父亲的环境做出反应，可以介导与父亲的环境暴露（例如饮食，精神压力）有关的某些表型的代际传递给后代。改进的分析工具开始破译精子RNA的复杂性，RNA修饰及其空间区隔化，这支持了在胚胎发育过程中编程特定后代表型的“精子RNA代码”概念。在这篇评论文章中，我讨论了巩固哺乳动物精子rna介导的表观遗传领域的挑战和机遇，包括鉴定负责父系表型传递的关键精子rna，以及胚胎发育过程中由精子rna触发的细胞和分子事件。我还讨论了通过利用精子RNA代码的知识来改善农场动物生产和人类健康的转化应用潜力。
Emerging evidence now shows that in addition to delivering a haploid DNA, the mammalian sperm also carry various types of RNAs that respond to the paternal environment, which can mediate the intergenerational transmission of certain phenotypes to the offspring relating to the paternal environmental exposures (e.g. diet, mental stress). Improved analytical tools are beginning to decipher the complexity of sperm RNAs, RNA modifications and their spatial compartmentalisation, which support the concept of ‘sperm RNA code’ in programming specific offspring phenotypes during embryonic development. In this commentary article, I discuss the challenges and opportunities in solidifying the field of mammalian sperm RNA-mediated epigenetic inheritance, including the identification of the key sperm RNAs that are responsible for the paternal phenotype transmission, and the cellular and molecular events that are triggered by sperm RNAs during embryo development. I also discuss the translational application potential by harnessing the knowledge of sperm RNA code to improve farm animal production and human health.