A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet
A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet
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DOI：
10.1007/s12263-007-0070-1
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发表时间：
2008-02-01
影响因子：
3.5
通讯作者：
Park, Taesun
中科院分区：
文献类型：
--
作者：
Kim, Yun Jung;Kim, Keun-Young;Park, Taesun
本研究旨在探讨黄藤提取物、大豆肽和左旋肉碱（1.2:0.3:0.02,w/w/w）对高脂饮食（HFD）致肥胖大鼠的抗肥胖作用。分别饲喂高脂对照饲粮（CD）和0.38%混合饲粮（CD + M） 9周。在hfd诱导的肥胖大鼠模型中，该混合物显著降低了体重增加和内脏脂肪量的积累。此外，该混合物有效降低了hfd诱导的肥胖大鼠的血液和肝脏脂质浓度以及血清葡萄糖、胰岛素、c肽和瘦素水平。实时逆转录聚合酶链反应结果显示，CD + M组大鼠附睾脂肪组织中瘦素、肿瘤坏死因子- α (tnf - α)和甾醇调节元件结合蛋白1c （SREBP1c）基因的表达量分别是CD组大鼠的0.4倍、0.6倍和0.48倍（P < 0.05）；而解偶联蛋白2 （UCP2）基因在附睾脂肪组织中的表达量是CD大鼠的1.25倍（P < 0.05）。综上所述，黄藤提取物、大豆肽和左旋肉碱组成的混合物可以减轻hfd诱导肥胖大鼠的内脏脂肪积累，改善血脂异常。
The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L-carnitine (1.2: 0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet ( CD) or the 0.38% mixture-supplemented HFD (CD + M) for 9 weeks. The mixture significantly reduced body weight gain and the accumulation of visceral fat mass in a rat model of HFD-induced obesity. Moreover, the mixture effectively lowered blood and hepatic lipid concentrations and serum glucose, insulin, c-peptide, and leptin levels in rats with HFD-induced obesity. Results from real-time reverse transcription-polymerase chain reaction analyses indicated that the expression levels of leptin, tumor necrosis factor-alpha (TNF-alpha), and sterol regulatory element binding protein 1c (SREBP1c) genes in the epididymal fat tissue of rats fed the CD + M diet were 0.4-, 0.6-, and 0.48-fold, respectively, of those found in the CD rats ( P < 0.05), while expression of the uncoupling protein 2 (UCP2) gene in epididymal adipose tissue was 1.25-fold (P < 0.05) of that found in CD rats. In conclusion, a mixture composed of G. cambogia extract, soy peptide, and L-carnitine attenuated visceral fat accumulation and improved dyslipidemia in a rat model with HFD-induced obesity.