The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat
The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat
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DOI：
10.1016/s0893-133x(99)00110-4
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发表时间：
2000-03-01
影响因子：
7.6
通讯作者：
Meaney, MJ
中科院分区：
文献类型：
--
作者：
Caldji, C;Francis, D;Meaney, MJ
我们比较了从出生后第二天到出生后第 14 天的处理或母体分离对大鼠对新鲜事物的行为反应以及 GABA(A) 和中枢苯二氮卓 (CBZ) 受体水平的影响。成年后，与处理组（H）和/或母体分离组（MS）相比，处理过的动物表现出惊吓反应性降低，在新的开放领域的探索增加，并且新奇引起的进食抑制减少。与经处理的动物相比，未经处理的（NH）和MS动物均表现出：（1）蓝斑（LC）和n中的GABA（A）受体水平降低。孤束 (NTS)； (2)减少中央和外侧的CBZ受体位点。杏仁核、额叶皮层以及 LC 和 NTS； (3) 杏仁核以及 LC 和 NTS 中 GABA(A) 受体复合物的 γ 2 亚基的 mRNA 水平降低，该受体复合物赋予 BZ 结合高亲和力。杏仁核和上行非肾上腺素系统都被认为是苯二氮卓类药物抗焦虑作用的关键部位。这些数据表明，早期生活事件影响 GABA(A) 受体系统的发育，从而改变成年期恐惧的表达。 [神经精神药理学 22:229-229, 2000] (C) 2000 美国神经精神药理学学院。由爱思唯尔科学公司出版
We compared the effects of handling or maternal separation from the day following birth until postnatal day 14 on behavioral responses to novelty and on GABA(A) and central benzodiazepine (CBZ) receptor levels in the rat. As adults, handled animals showed reduced startle responsivity, increased exploration in a novel open field, and decreased novelty-induced suppression of feeding relative to the handled (H) and/or maternal separation (MS) groups. As compared with handled animals, both nonhandled (NH) and MS animals displayed: (1) reduced GABA(A) receptor levels in the locus coeruleus (LC) and the n. tractus solitarius (NTS); (2) reduced CBZ receptor sites in the central and lateral n. of the amygdala, the frontal cortex, and in the LC and NTS; and (3) reduced levels of the mRNA for the gamma 2 subunit of the GABA(A) receptor complex, which confers high affinity BZ binding, in the amygdaloid nucleic as well as the he LC and NTS. Both the amygdala and the ascending nonadrenergic systems have been considered as critical sites for the anxiolytic effects of benzodiazepines. These data suggest that early life events influence the development of the GABA(A) receptor system, thus altering the expression of fearfulness in adulthood. [Neuropsychopharmacology 22:229-229, 2000] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.