EXCITATORY SYNAPTIC ACTION IN MOTONEURONES
EXCITATORY SYNAPTIC ACTION IN MOTONEURONES
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DOI：
10.1113/jphysiol.1955.sp005413
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发表时间：
1955-01-01
影响因子：
5.5
通讯作者：
FATT, P
中科院分区：
文献类型：
--
作者：
COOMBS, JS;ECCLES, JC;FATT, P
本文研究了膜电位对麻醉猫脊髓运动神经元兴奋性突触后电位（epsp）的影响。通过双管细胞内微电极的一个桶施加电流来改变运动神经元的膜电位，而另一个桶则观察到电位。注射到运动神经元的一些不同种类的阳离子和阴离子进行了研究。这些离子对epsp都没有特异性作用。特别是，Na离子虽然减少和减缓了尖峰，但epsp保持不变。这一结果与短路假说一致，短路假说要求在epsp产生过程中，膜对所有种类的离子的渗透性经历非选择性增加。还报道了由epsp的去极化作用和epsp的时程建立尖峰的观察结果，包括epsp初始去极化之后的延长的超极化。
Effect of membrane potential on the excitatory post-synaptic potential (epsp) of the spinal motoneurone of the anesthetized cat was studied. The membrane potential of a motoneurone was varied by applying current through one barrel of a double-barrelled intracellular microelectrode, while potentials were seen with the other barrel. Injection into motoneurones of a number of different species of cations and anions was investigated. None of these ions had a specific effect on the epsp. In particular, Na ions while decreasing and slowing the spike, left the epsp unchanged. This result is in agreement with the short-circuit hypothesis, which requires that during the generation of the epsp the membranes undergo a non-selective increase in permeability toward ions of all species. Observations were reported also on the setting up of a spike by the depolarizing action of the epsp and on the time course of the epsp, including the prolonged hyperpolarization that follows the initial depolarization of the epsp.