Immunosurveillance of Candida albicans commensalism by the adaptive immune system.
Immunosurveillance of Candida albicans commensalism by the adaptive immune system.
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DOI：
10.1038/s41385-022-00536-5
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发表时间：
2022-05
影响因子：
8
通讯作者：
LeibundGut-Landmann, Salome
中科院分区：
文献类型：
--
作者：
Swidergall, Marc;LeibundGut-Landmann, Salome
真菌微生物群（mycobiota）是定殖于身体表面的微生物群落的组成部分，并且涉及人类生理学的许多关键方面，而真菌群落的不平衡，称为真菌生态失调，已经在从感染到炎性肠病的病理学中描述。共生生物，如真菌白色念珠菌，诱导抗原特异性免疫应答，维持免疫稳态。适应性免疫机制在这一过程中至关重要，而适应性免疫的缺陷与真菌感染有关。我们开始了解真菌生物群组成变化的机制，特别是在C。白色念珠菌丰度与免疫病理学状况有关。本文综述了保证C.这些保护性适应性免疫反应如何也能促进免疫病理学，并突出了针对C.白色念珠菌相关疾病
The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to inflammatory bowel disease. Commensal organisms, such as the fungus Candida albicans, induce antigen-specific immune responses that maintain immune homeostasis. Adaptive immune mechanisms are vital in this process, while deficiencies in adaptive immunity are linked to fungal infections. We start to understand the mechanisms by which a shift in mycobiota composition, in particular in C. albicans abundance, is linked to immunopathological conditions. This review discusses the mechanisms that ensure continuous immunosurveillance of C. albicans during mucosal colonization, how these protective adaptive immune responses can also promote immunopathology, and highlight therapeutic advances against C. albicans-associated disease.
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影响因子：
4.4
作者：
Baer, Eva;Gadiator, Andre;LeibundGut-Landmann, Salome
通讯作者：
LeibundGut-Landmann, Salome
影响因子：
30.5
作者：
Alves de Lima K;Rustenhoven J;Da Mesquita S;Wall M;Salvador AF;Smirnov I;Martelossi Cebinelli G;Mamuladze T;Baker W;Papadopoulos Z;Lopes MB;Cao WS;Xie XS;Herz J;Kipnis J
通讯作者：
Kipnis J
影响因子：
28.3
作者：
Ballou ER;Avelar GM;Childers DS;Mackie J;Bain JM;Wagener J;Kastora SL;Panea MD;Hardison SE;Walker LA;Erwig LP;Munro CA;Gow NA;Brown GD;MacCallum DM;Brown AJ
通讯作者：
Brown AJ
影响因子：
25.7
作者：
Demir M;Lang S;Hartmann P;Duan Y;Martin A;Miyamoto Y;Bondareva M;Zhang X;Wang Y;Kasper P;Bang C;Roderburg C;Tacke F;Steffen HM;Goeser T;Kruglov A;Eckmann L;Stärkel P;Fouts DE;Schnabl B
通讯作者：
Schnabl B
影响因子：
5.5
作者：
Doherty, Mark;Buchy, Philippe;Prado-Cohrs, David
通讯作者：
Prado-Cohrs, David