Wound Pain and Wound Healing Biomarkers From Wound Exudate: A Scoping Review.
Wound Pain and Wound Healing Biomarkers From Wound Exudate: A Scoping Review.
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DOI：
10.1097/won.0000000000000703
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发表时间：
2020
影响因子：
2.6
通讯作者：
Saligan, Leorey N.
中科院分区：
文献类型：
--
作者：
Goto, Taichi;Saligan, Leorey N.
有效管理伤口疼痛对于最佳伤口愈合至关重要。然而，伤口疼痛干预的结果是基于主观测量的，这在认知障碍患者中可能是有问题的。鉴定与伤口疼痛和伤口愈合相关的生物标志物可以客观地估计伤口疼痛，并有助于开发精确的管理方案，以减少伤口疼痛和促进伤口愈合。本范围审查旨在从伤口渗出物中识别伤口疼痛和伤口愈合生物标志物，并描述不同的伤口收集方法以识别这些生物标志物。我们通过范围审查检索了文献（PROSPERO数据库注册号：CRD 42018103843）。检索PubMed数据库中探索皮肤伤口疼痛、伤口愈合和生物分子之间关系的文章。纳入标准为报告原始数据、使用成人样本并以英文发表的文章。检索到21篇文章; 17篇研究了与伤口愈合状态相关的伤口渗出液分子，4篇报告了与伤口疼痛相关的分子。最常见的伤口疼痛生物标志物是促炎细胞因子;最常见的伤口愈合生物标志物是蛋白酶，包括基质金属蛋白酶家族中的蛋白酶。确定了六种伤口渗出液收集方法，以从伤口渗出液中提取潜在的伤口疼痛和伤口愈合生物标志物。这些结果可以指导未来的伤口渗出物研究，以验证这些伤口疼痛和伤口愈合生物标志物，并开发针对这些生物标志物的治疗方法，以减少伤口疼痛和促进伤口愈合。
Effective management of wound pain is essential for optimal wound healing. Nevertheless, the outcomes of wound pain interventions are based on subjective measures, which can prove problematic in patients with cognitive impairment. Identification of biomarkers associated with wound pain and wound healing can objectively estimate wound pain and contribute to the development of precise management options to reduce wound pain and promote wound healing. This scoping review aimed to identify wound pain and wound healing biomarkers from wound exudates, and to describe different wound collection methods to identify these biomarkers. We searched the literature (PROSPERO database registration number: CRD42018103843) via a scoping review. The PubMed database was searched for articles that explored relationships between cutaneous wound pain, wound healing and biomolecules. Inclusion criteria were articles that reported original data, used adult human samples, and were published in English. Twenty-one articles were retrieved; 17 investigated molecules from wound exudate associated with wound healing status, and 4 reported molecues associated with wound pain. The most frequently observed wound pain biomarkers were pro-inflammatory cytokines; the most frequently observed wound healing biomarkers were proteases including those in the matrix metalloproteinase family. Six wound exudate collection methods were identified to extract potential wound pain and wound healing biomarkers from wound exudate. The results can guide future wound exudate research to validate these wound pain and wound healing biomarkers and to develop therapies targeting these biomarkers to reduce wound pain and promote wound healing.