DIETARY CARCINOGENS AND ANTICARCINOGENS - OXYGEN RADICALS AND DEGENERATIVE DISEASES
DIETARY CARCINOGENS AND ANTICARCINOGENS - OXYGEN RADICALS AND DEGENERATIVE DISEASES
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DOI：
10.1126/science.6351251
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
AMES, BN
中科院分区：
文献类型：
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作者：
AMES, BN
人类饮食中含有大量的天然诱变剂和致癌物，以及许多天然抗诱变剂和抗癌剂。许多这些诱变剂和致癌物可能通过产生氧自由基而起作用。氧自由基也可能作为退行性过程的内源性引发剂发挥重要作用，例如DNA损伤和突变（和促进），这可能与癌症，心脏病和衰老有关。天然抗氧化剂的饮食摄入量可能是身体防御机制的一个重要方面。许多抗氧化剂被确定为抗癌剂。表征和优化这种防御系统可能是减少癌症和其他年龄相关疾病的战略的重要组成部分。
The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.