Decision making in Parkinson's disease: Analysis of behavioral and physiological patterns in the Iowa Gambling Task
Decision making in Parkinson's disease: Analysis of behavioral and physiological patterns in the Iowa Gambling Task
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DOI：
10.1002/mds.21865
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发表时间：
2008-03-15
影响因子：
8.6
通讯作者：
Kawamura, Mitsuru
中科院分区：
文献类型：
--
作者：
Kobayakawa, Mutsutaka;Koyama, Shinichi;Kawamura, Mitsuru
最近的研究表明，社会认知过程受到帕金森病（PID）的影响。然而，PID患者是否表现出行为改变仍然存在争议。本研究的目的是检查PD患者执行爱荷华州赌博任务（IGT）的决策。我们招募了大量的早期，非痴呆PD患者的IGT。我们还记录了任务期间的皮肤电反应（SCRS）作为情绪唤醒的测量。与正常对照组（NC）相比，PD患者在IGT中选择了更多的不利卡片，决策前和接受奖惩后的SCR均低于NC组。风险选择的倾向与年龄、教育程度、整体认知功能或疾病的严重程度无关。这些结果证实了PI患者的决策受到疾病的影响，而不是其他认知功能的影响;此外，这种行为与较低的情绪反应有关。PD患者的行为和SCR模式与杏仁核损伤患者相似。帕金森病患者对风险选择的反应偏差可能是杏仁核功能障碍所致，杏仁核功能障碍与风险评估有关。(C)2007年，《社会运动》创刊。
Recent studies suggest that social recognition processes are affected by Parkinson's disease (PID). However, whether PID patients exhibit behavioral changes is still controversial. The Purpose of the present Study was to examine the decision making of PD patients performing the Iowa Gambling Task (IGT). We recruited a large number of early, nondemented PD patients for the IGT. We also recorded the skin conductance responses (SCRS) during the task as a measure of emotional arousal. Compared with the normal control (NC) Subjects, PD patients selected more disadvantageous decks in the IGT, and their SCRs were lower than those of NC subjects before making decisions and after receiving reward or punishment. The tendency toward risky choices was not correlated with age, education, global cognitive function, or the severity of the disease. These results confirmed that the decision making of PI) patients was affected by the disease, rather than by other cognitive functions; moreover, such behavior was related to lower emotional responses. Behavioral and SCR patterns of PD patients were similar to those of amygdala-damaged patients. The response bias toward risky choices in PD may be explained by the dysfunction of the amygdala, which is known to be involved in risk evaluation. (C) 2007 Movement Disorder Society.