Interethnic differences in the detoxification of organophosphates: the human serum paraoxonase polymorphism.
Interethnic differences in the detoxification of organophosphates: the human serum paraoxonase polymorphism.
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有机磷酸酯解毒的种族间差异：人血清对氧磷酶多态性。
DOI：
10.1007/978-3-642-71248-7_18
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Geldmacher
中科院分区：
文献类型：
--
作者：
T. Diepgen;M. Geldmacher
对氧磷，0，0-二乙基-0-对硝基苯磷酸盐是氯磷磷的高毒性代谢产物。对氧磷酶是水解人血清中对氧磷的酶，其活性表现出受遗传影响的多态性，具有很强的种族间差异。血清对氧磷酶基因型对对氧磷清除率有显著影响，因此对氧磷和一些相关有机磷的毒性作用有显著影响，并明确保护血清胆碱酯酶。对氧磷酶活性低的人在处理敌百虫和相关杀虫剂时似乎更危险。超过50%的欧洲人可以被包括在这个群体中。将显示从世界各地采集的样本中人血清中对氧磷酶活性的分布。随着从欧洲向非洲和亚洲方向移动，低活动组的百分比下降，甚至在某些部落中无法证明。
Paraoxon, 0,0-diethyl-0-p-nitrophenylphosphate is the highly toxic metabolite of parathion. The activity of paraoxonase, the enzyme which hydrolyses paraoxon in human serum shows a genetically influenced polymorphism with strong interethnic differences. The serum paraoxonase genotype has a significant influence on the paraoxon clearance and consequently on the toxic action of paraoxon and some related organophosphates and definitively protects the serum cholinesterase. Persons with low paraoxonase activity seem to be more endangered when handling parathion and related insecticides. More than 50% of all Europeans can be included in this group. The distribution of paraoxonase activity in human serum will be shown for samples which were collected from all over the world. As one moves from Europe in the direction of Africa and Asia the percentage of the low activity group decreases and was not even demonstrable in some tribes.
人血清对氧磷酶多态性：通过对盐的反应鉴定表型。
影响因子：
9.8
作者：
Eckerson,HW;Romson,J;Wyte,C;LaDu,BN
通讯作者：
LaDu,BN
影响因子：
9.8
作者：
R. Mueller;S. Hornung;C. Furlong;J. Anderson;E. Giblett;A. Motulsky
通讯作者：
R. Mueller;S. Hornung;C. Furlong;J. Anderson;E. Giblett;A. Motulsky