Comparative studies between pathogenesis of street and fixed rabies infection.
Comparative studies between pathogenesis of street and fixed rabies infection.
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DOI：
10.1084/jem.125.3.447
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发表时间：
1967-03-01
期刊：
影响因子：
--
通讯作者：
Matsumoto S
中科院分区：
文献类型：
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作者：
Miyamoto K;Matsumoto S
通过光学和电子显微镜相结合的方式研究了街头狂犬病感染和固定狂犬病感染引起的阿蒙角神经病理学的比较。含有内格里体的神经元似乎受到的损伤相对较小。与此形成鲜明对比的是，在固定病毒感染的情况下，神经元表现出以下各种变性。轻度受损的神经元显示出整个细胞质中小囊泡数量的增加。这些神经细胞内还遇到了大量的溶酶体。在神经细胞带中发现涉及细胞核和细胞质的严重坏死改变。这些神经元内的特征同质焦点（矩阵）是可辨别的。看来该基质在形态上与内格里体的基质相同，尽管其尺寸小于内格里体。这一证据表明固定病毒可能对神经元造成如此广泛的伤害，以至于它们无法使光学显微镜可识别的内格里体特征基质完全发育。在街道病毒和固定病毒感染的细胞病变机制方面，不同神经元组之间显示出选择性脆弱性。
Comparative neuropathology of Ammon's horn caused by both the street and fixed rabies infection was studied by combined light and electron microscopy. Neurons containing Negri bodies appeared comparatively little damaged. In striking contrast, in the case of fixed virus infection, neurons showed the following variety of degeneration. Lightly damaged neurons showed an increase in the number of small vesicles throughout the cytoplasm. A considerable number of lysosomes were also encountered within these nerve cells. Severe necrotic alteration involving the nucleus as well as the cytoplasm was found in the nerve cell band. The characteristic homogeneous foci (matrices) were discernible within these neurons. It appears that the matrix is morphologically identical with the ground substance of the Negri body, though its size is smaller than that of the Negri body. This evidence suggests a possibility that fixed virus injures neurons so extensively that they cannot bring about the full development of the characteristic matrix of the Negri body recognizable by the light microscope. Selective vulnerability was demonstrated among different groups of neurons in respect of cytopathogenesis of both street and fixed virus infection.