Language lateralization development in children with autism: Insights from the late field magnetoencephalogram
Language lateralization development in children with autism: Insights from the late field magnetoencephalogram
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DOI：
10.1016/j.neulet.2005.05.037
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发表时间：
2005-09-30
影响因子：
2.5
通讯作者：
Roberts, TPL
中科院分区：
文献类型：
--
作者：
Flagg, EJ;Cardy, JEO;Roberts, TPL
对于大多数神经学健康的右撇子来说，左半球优势代表了典型的语言偏侧化特征。我们研究了自闭症语言障碍儿童和典型发育对照儿童的大脑半球语言优势，以探讨语言的非典型功能专门化代表自闭症发育性语言障碍的一个组成部分的假设。迟场脑磁图(MEG)记录被用来根据被动听觉呈现元音刺激诱发的神经磁性活动计算半球偏侧化指数。结果表明，自闭症儿童和典型发育儿童在语言偏侧化方面遵循相反的成熟轨迹；在我们的典型发育儿童样本中，随着年龄的增加，左侧化(即左半球优势)来自于双侧对称神经元的激活，而在我们的自闭症儿童样本中，随着年龄的增长，双侧对称活动出现了向右偏侧化。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Left hemisphere dominance represents the typical language lateralization profile for the majority of neurologically healthy, right-handed individuals. We investigated hemispheric dominance for language in language-impaired children with autism and typically developing controls to investigate the hypothesis that atypical functional specialization for language represents one component of developmental language impairment in autism. Late field magnetoencephalography (MEG) recordings were used to calculate a hemispheric Lateralization Index from the neuromagnetic activity evoked by passive auditory presentation of vowel stimuli. Results indicate that children with autism and typically developing children follow opposite maturational trajectories in language lateralization; while leftward lateralization (i.e. left hemisphere dominance) emerged from bilaterally symmetric neuronal activation as age increased in our sample of typically developing children, rightward lateralization emerged from bilaterally symmetric activity as age increased in our sample of children with autism. (C) 2005 Elsevier Ireland Ltd. All rights reserved.