Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children
Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children
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DOI：
10.1210/jc.2007-0468
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发表时间：
2007-11-01
影响因子：
5.8
通讯作者：
Zimmermann, Michael B.
中科院分区：
文献类型：
--
作者：
Aeberli, Isabelle;Biebinger, Ralf;Zimmermann, Michael B.
内容：尽管在肥胖和胰岛素抵抗（IR）的动物模型中，视黄醇结合蛋白（RBP）-4浓度升高，但RBP 4与人类IR之间的联系尚不清楚。关于超重儿童RBP 4水平的已发表数据很少，并且大多数先前的研究没有控制维生素A（VA）状态和/或亚临床炎症。目的：本研究的目的是测量正常体重和超重儿童的血清RBP 4、血清视黄醇（SR）、RBP 4与SR摩尔比和膳食VA摄入量，并研究这些变量与IR的关系，亚临床炎症和代谢综合征在这个年龄组。设计：这是一个横断面研究。设置：这项研究在瑞士北方进行。患者：患者包括6- 14岁正常体重，超重和肥胖儿童（n = 79）。主要结果测量：测定体重指数、体脂百分比、腰臀比、膳食VA摄入量、血清RBP 4和SR。IR进行了评估，使用空腹胰岛素和定量胰岛素敏感性检查指数，代谢综合征和亚临床炎症指标的组成部分进行了measured.Results：只有3%的儿童有低VA状态。独立于年龄、VA摄入量和C-反应蛋白，体重指数、体脂百分比和腰臀比是RBP 4、SR和RBP 4/SR的显著预测因子。独立于肥胖，RBP 4和RBP 4/SR与血清甘油三酯显著相关，RBP 4/SR与空腹胰岛素相关。RBP 4/SR比值与代谢综合征各组分的相关性高于血清RBP 4。结论：在青春期前和青春期早期儿童中，血清RBP 4和RBP 4/SR比值与肥胖、向心性肥胖和代谢综合征各组分相关，与亚临床炎症和维生素A摄入无关。
Context: Although retinol-binding protein ( RBP)-4 concentrations are elevated in animal models of obesity and insulin resistance ( IR), the link between RBP4 and IR in humans is less clear. There are few published data on RBP4 levels in overweight children, and most previous studies did not control for vitamin A ( VA) status and/or subclinical inflammation.Objective: The objective of the study was to measure serum RBP4, serum retinol ( SR), the RBP4-to-SR molar ratio, and dietary VA intakes in normal-weight and overweight children and investigate the relationship of these variables to IR, subclinical inflammation, and the metabolic syndrome in this age group.Design: This was a cross-sectional study.Setting: The study was conducted in Northern Switzerland.Patients: Patients included 6- to 14-yr-old normal-weight, overweight, and obese children ( n = 79).Main Outcome Measures: Body mass index, body fat percentage, waist-to-hip ratio, dietary VA intakes, serum RBP4, and SR were determined. IR was assessed using fasting insulin and the quantitative insulin sensitivity check index, and components of the metabolic syndrome and indices of subclinical inflammation were measured.Results: Only 3% of children had low VA status. Independent of age, VA intakes, and C-reactive protein, body mass index, body fat percentage, and waist-to-hip ratio were significant predictors of RBP4, SR, and RBP4/SR. Independent of adiposity, RBP4 and RBP4/SR were significantly correlated with serum triglycerides, and RBP4/SR was correlated with fasting insulin. The RBP4-to-SR ratio more strongly correlated with components of the metabolic syndrome than serum RBP4.Conclusion: Independent of subclinical inflammation and vitamin A intakes, serum RBP4 and the RBP4-to-SR ratio are correlated with obesity, central obesity, and components of the metabolic syndrome in prepubertal and early pubertal children.