Long-term Impact of Childhood Adiposity on Adult Metabolic Syndrome Is Modified by Insulin Resistance: The Bogalusa Heart Study.
Long-term Impact of Childhood Adiposity on Adult Metabolic Syndrome Is Modified by Insulin Resistance: The Bogalusa Heart Study.
复制标题
胰岛素抵抗改变了儿童肥胖对成人代谢综合征的长期影响：Bogalusa 心脏研究。
DOI：
10.1038/srep17885
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发表时间：
2015-12-07
影响因子：
4.6
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Zhang H;Zhang T;Li S;Li Y;Hussain A;Fernandez C;Harville E;Bazzano LA;He J;Chen W
儿童肥胖和胰岛素抵抗是成人代谢综合征(METS)的众所周知的危险因素。这项研究的目的是检验儿童肥胖和成年后代谢综合征之间的联系是否被胰岛素抵抗所改变。队列包括1593名黑人和白人受试者，年龄在19-50岁之间，他们在儿童时期和成年后平均相隔19岁接受METS变量检查。比较了儿童时期胰岛素敏感型肥胖组和胰岛素抵抗肥胖组成人METS的患病率。胰岛素抵抗肥胖组的成人代谢综合征患病率高于胰岛素敏感型肥胖组(34.9%比24.3%，p = 0.008)。在对年龄、种族、性别和随访年限进行调整的多变量Logistic回归分析中，儿童期胰岛素抵抗肥胖者平均比儿童期胰岛素敏感型肥胖者晚19年发生METS的可能性高1.7%(p = 0.011)。黑人和白人的优势比没有显著差异(p = 0.724)。儿童体重指数与成年Met的关系的OR值随着儿童HOMA的增加而显著增加(p <； 0.001为趋势)。这些发现表明，胰岛素抵抗放大了儿童肥胖症和成年METS之间的联系，并强调了在早期生活中预防肥胖症和胰岛素抵抗的重要性。
Childhood adiposity and insulin resistance are well-known risk factors for adult metabolic syndrome (MetS). This study aims to examine whether the association between childhood adiposity and adult MetS is modified by insulin resistance. The cohort consisted of 1,593 black and white subjects, aged 19–50 years at follow-up, who were examined 19 years apart on average as children and adults for MetS variables. The prevalence of adult MetS was compared between the insulin-sensitive obesity and insulin-resistant obesity groups in childhood. Adult MetS prevalence was higher in the insulin-resistant obesity group than in the insulin-sensitive obesity group (34.9% vs. 24.3%, p = 0.008). In multivariable logistic regression analyses adjusted for age, race, gender, and follow-up years, individuals with insulin-resistant obesity in childhood were 1.7 times (p = 0.011) more likely to have MetS 19 years later on average than those with insulin-sensitive obesity in childhood. Odds ratio did not differ significantly between blacks and whites (p = 0.724). ORs for the association of childhood BMI with adult MetS significantly increased with increasing tertiles of childhood HOMA (p < 0.001 for trend). These findings suggest that insulin resistance amplifies the association between childhood adiposity and adult MetS and underscore the importance of preventing both adiposity and insulin resistance in early life.