Nonalcoholic fatty liver disease and the ongoing role of liver biopsy evaluation.
Nonalcoholic fatty liver disease and the ongoing role of liver biopsy evaluation.
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DOI：
10.1002/hep4.1055
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发表时间：
2017-07
影响因子：
5.1
通讯作者：
Brunt EM
中科院分区：
文献类型：
--
作者：
Brunt EM
非酒精性脂肪性肝病（NAFLD）是全球成人和儿童肝脏检查和肝病慢性升高的最常见潜在原因之一，如果没有通过不断发展和可用的血清学和基于成像的非侵入性检查进行诊断，则可能强烈怀疑。然而，NAFLD最进展形式的明确诊断，非酒精性脂肪性肝炎和纤维化阶段的鉴定仍然需要肝活检评估，因为无创性检测尚未取代肝活检可获得的一些细节或全部信息。在这篇综述中，肝活检评估在NAFLD/非酒精性脂肪性肝炎中的作用和价值都来自与选定的各种环境相关的出版物。最常用的半定量分析方法的细节进行了讨论，并给出了一些有用的潜在的陷阱，在肝活检的解释鉴别诊断的考虑。（Hepatology Communications 2017;1：370-378）
Nonalcoholic fatty liver disease (NAFLD) is one of the most common underlying causes of chronically elevated liver tests and liver disease in adults and children worldwide and may be strongly suspected if not diagnosed by ever evolving and available serologic and imaging‐based noninvasive tests. However, the definitive diagnosis of the most progressive form of NAFLD, nonalcoholic steatohepatitis, and the identification of fibrosis stage still require liver biopsy evaluation as noninvasive testing has not replaced some of the specifics or the totality of information obtainable from liver biopsy. In this review, both the role and value of a liver biopsy evaluation in NAFLD/ nonalcoholic steatohepatitis are examined from publications related to a selected variety of settings. Details of the most commonly used semiquantitative methods of analysis are discussed, and some useful potential pitfalls for differential diagnostic consideration in liver biopsy interpretation are given. (Hepatology Communications 2017;1:370–378)
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影响因子：
29.4
作者：
Angulo P;Kleiner DE;Dam-Larsen S;Adams LA;Bjornsson ES;Charatcharoenwitthaya P;Mills PR;Keach JC;Lafferty HD;Stahler A;Haflidadottir S;Bendtsen F
通讯作者：
Bendtsen F
影响因子：
13.5
作者：
Bedossa, Pierre;Moucari, Rami;Marcellin, Patrick
通讯作者：
Marcellin, Patrick
影响因子：
5.1
作者：
Clouston, Andrew D;Jonsson, Julie R;Powell, Elizabeth E
通讯作者：
Powell, Elizabeth E
影响因子：
13.5
作者：
Kleiner, DE;Brunt, EM;Sanyal, AJ
通讯作者：
Sanyal, AJ
DOI：
10.1002/hep.29085
发表时间：
2017-05
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Dulai PS;Singh S;Patel J;Soni M;Prokop LJ;Younossi Z;Sebastiani G;Ekstedt M;Hagstrom H;Nasr P;Stal P;Wong VW;Kechagias S;Hultcrantz R;Loomba R
通讯作者：
Loomba R