An extracellular matrix infrastructure provides support for murine secondary palatal shelf remodelling
An extracellular matrix infrastructure provides support for murine secondary palatal shelf remodelling
复制标题
细胞外基质基础设施为小鼠次级腭架重塑提供支持
DOI：
--
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
L. Brinkley
中科院分区：
文献类型：
--
作者：
J. Morris;L. Brinkley
第二腭形态发生的一个关键部分是腭架从舌两侧的初始垂直位置移动到舌上方的最终水平位置，以实现腭闭合。细胞外基质（ECM）分子的免疫细胞化学定位在腭架在此重塑和重新定位揭示了间充质内的ECM基础设施的存在。该基础结构的主要成分是胶原蛋白III、纤连蛋白和透明质酸盐（HA）。随着重塑，HA在间充质内的结构域扩大，而纤连蛋白和胶原III的结构域变得更加局限。间充质内富含HA的基质的扩张被认为是腭重定向的关键。这项研究的结果表明，当这种扩张发生时，它是由ECM基础结构的胶原蛋白和纤连蛋白组分调节的。在货架重塑之前，这种基础结构可以通过口腔中上皮-间充质界面的专门区域和下颌下间充质锚定，其特征在于胶原蛋白III、纤连蛋白和腱生蛋白的独特分布。口中腭上皮也可能在引导货架扩张中发挥作用。该上皮区域经历与货架重塑相关的细胞包装和上皮细胞分层的变化。这些变化伴随着下面的基底膜内的胶原蛋白III、胶原蛋白IV和层粘连蛋白的表达的变化而发生。腱生蛋白在发育中的腭中的定位和模式表明，它不仅有助于口腔中上皮-间充质区域的假定锚定结构，而且在腭闭合的最后阶段决定中缘上皮细胞的命运中发挥作用。© Willey利斯，Inc.
A cricial part of secondary palate morphogenesis is the movement of the palatal shelves from an initial vertical position on either side of the tongue to a final horizontal one above it to achieve palate closure. The immunocytochemical localization of extracellular matrix (ECM) molecules in the palatal shelf during this remodelling and reorientation revealed the existence of an ECM infrastructure within the mesenchyme. The major components of this infrastructure were collagen III, fibronectin, and hyaluronate (HA). With remodelling, HA's domain within the mesenchyme was expanded, whereas those of fibronectin and collagen III became more circumscribed. The expansion of an HA‐rich matrix within the mesenchyme is thought to be crucial for palatal reorientation. The results of this study suggest that, as this expansion occurs, it is modulated by collagen and fibronectin components of the ECM infrastructure. Prior to shelf remodelling, this infrastructure may be anchored by a specialized region of the midoral epithelial‐mesenchymal interface and the subjacent mesenchyme which is characterized by the unique distribution of collagen III, fibronectin, and tenascin. The midoral palatal epithelium also may play a role in directing shelf expansion. This epithelial region undergoes changes in cell packing and epithelial cell layering that correlate with shelf remodelling. These changes occur concomitantly with changes in the expression of collagen III, collagen IV, and laminin within the underlying basement membrane. The localization and patterning of tenascin within the developing palate suggests that it not only contributes to the postulated anchoring structure of the midoral epithelial‐mesenchymal region, but also plays a role in the determining the fate of the medial edge epithelial cells during the final stage of palate closure.© Willey‐Liss, Inc.
登录
查看更多内容
氯环嗪诱导的糖胺聚糖改变对体内和体外小鼠腭架升高的影响。
DOI：
--
发表时间：
1982
期刊：
Journal of embryology and experimental morphology
影响因子：
--
作者：
Brinkley,LL;Vickerman,MM
通讯作者：
Vickerman,MM
DOI：
10.1146/annurev.cb.05.110189.000443
发表时间：
1989-01-01
期刊：
ANNUAL REVIEW OF CELL BIOLOGY
影响因子：
--
作者：
ERICKSON, HP;BOURDON, MA
通讯作者：
BOURDON, MA
影响因子：
2.7
作者：
FITCHETT, JE;HAY, ED
通讯作者：
HAY, ED
小鼠次级腭形态发生过程中透明质酸分布的计算机辅助分析。
DOI：
10.1242/dev.100.4.629
发表时间：
1987
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Brinkley,LL;Morris-Wiman,J
通讯作者：
Morris-Wiman,J