Childhood lipoprotein profiles and implications for adult coronary artery disease: the Bogalusa Heart Study.
Childhood lipoprotein profiles and implications for adult coronary artery disease: the Bogalusa Heart Study.
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DOI：
10.1097/00000441-199512000-00011
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发表时间：
1995-12
期刊：
影响因子：
--
通讯作者：
S. Srinivasan;G. Berenson
中科院分区：
文献类型：
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作者：
S. Srinivasan;G. Berenson
血清脂蛋白是冠心病的重要危险因素。对大量年轻人的研究表明，儿童时期脂蛋白的变化具有种族（黑人-白人）和性别特异性，并且在生长阶段发生某些变化。白色男孩在性成熟过程中表现出脂蛋白水平的不利变化，这标志着他们处于CAD的高风险中。此外，低密度脂蛋白颗粒是相对富集在白色儿童中的载脂蛋白B，特别是男孩，这是与低水平的高密度脂蛋白胆固醇相关的特征。载脂蛋白E基因型对成人血清脂蛋白的影响在儿童中已经很明显，这可能有助于识别高危人群。在父母心肌梗死和后代脂蛋白变量水平方面，对儿童-父母相关性的观察表明，儿童时期脂蛋白（a）、载脂蛋白A-I和载脂蛋白B谱可能有助于作为未来CAD的标志物。躯干脂肪、胰岛素和血压水平升高的聚集常见于脂蛋白谱不良的年轻人。这种聚集与儿童期碳水化合物和脂质代谢的细微异常以及肥胖有关。脂蛋白水平从儿童期持续到青年期的事实强调了在生命早期检测和管理血脂异常的重要性。
Serum lipoproteins are important risk factor variables for coronary artery disease (CAD). Studies of a large population of young individuals show changes in lipoproteins in childhood are race- (black-white) and sex-specific and certain changes occur during growth phases. White boys show adverse changes in lipoprotein levels during sexual maturation that mark them at high risk for CAD. Further, low-density lipoprotein particles are relatively apolipoprotein B enriched in white children, especially boys, a characteristic associated with low levels of high-density lipoprotein cholesterol. The impact of apolipoprotein E genotype on serum lipoproteins seen in adults is already apparent in children, which may be helpful in identifying a high-risk group. Observations of child-parent associations in terms of parental myocardial infarction and levels of lipoprotein variables in the offspring suggest that childhood profiles of lipoprotein (a), apolipoprotein A-I, and apolipoprotein B may be helpful as markers of future CAD. Clustering of increased levels of truncal fat, insulin, and blood pressure is often seen in young adults with an adverse lipoprotein profile. This clustering is related to subtle abnormalities in carbohydrate and lipid metabolism and obesity in childhood. The fact that lipoprotein levels persist from childhood to young adulthood underscores the importance of detection and management of dyslipidemia early in life.