Origins of the electroretinogram oscillatory potentials in the rabbit retina
Origins of the electroretinogram oscillatory potentials in the rabbit retina
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DOI：
10.1017/s0952523804214043
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发表时间：
2004-07-01
影响因子：
1.9
通讯作者：
Hare, WA
中科院分区：
文献类型：
--
作者：
Dong, CJ;Agey, P;Hare, WA
视网膜电图（ERG）振荡电位（OP）是一种叠加在b波上升相上的高频、低振幅电位。它提供了无创的评价内视网膜功能在体内，是一个有用的工具，在基础研究以及在临床上。虽然OP被广泛认为主要是由内层视网膜的活动产生的，但确切的潜在神经机制还没有很好地理解。我们已经调查了视网膜的机制，在荷兰带兔OP代的基础。通过带通滤波（100-1000 Hz）ERG信号隔离OP。我们使用了阻断特定递质受体或电压门控通道的药物，以检查各种视网膜机制对OP产生的贡献。我们的研究结果表明，由明亮的短暂闪光引起的OP可以分为早期，中期和晚期亚组，可能主要由光感受器，动作电位独立的，动作电位依赖的机制，分别在内视网膜的ON通路中产生。ON双极细胞本身对OP产生的直接贡献很小，OFF通路中的水平细胞和神经元也是如此。
The electroretinogram (ERG) oscillatory potential (OP) is a high-frequency, low-amplitude potential that is superimposed on the rising phase of the b-wave. It provides noninvasive evaluation of inner retina function in vivo and is a useful tool in basic research as well as in the clinic. While the OP is widely believed to be generated mainly by activity of the inner retina, the exact underlying neural mechanisms are not well understood. We have investigated the retinal mechanisms that underlie OP generation in Dutch-belted rabbits. The OP was isolated by band-filtering (100-1000 Hz) ERG signals. We used pharmacological agents that block specific transmitter receptors or voltage-gated channels in order to examine contributions of various retinal mechanisms to OP generation. Our results show that the OP elicited by a bright brief flash can be classified into early, intermediate, and late subgroups that are likely generated mainly by photoreceptors, action-potential-independent, and action-potential-dependent mechanisms in the ON pathway of the inner retina, respectively. ON bipolar cells themselves make only a small direct contribution to OP generation, as do horizontal cells and neurons in the OFF pathway.