Cancer of the gastrointestinal tract results in a restricted T-cell repertoire dependent upon tumor differentiation
Cancer of the gastrointestinal tract results in a restricted T-cell repertoire dependent upon tumor differentiation
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胃肠道癌症导致 T 细胞库受限，具体取决于肿瘤分化
DOI：
10.1016/j.cellimm.2011.03.024
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发表时间：
2011-01-01
影响因子：
4.3
通讯作者：
Ma, Li
中科院分区：
文献类型：
--
作者：
Luo, Wei;Liao, Wang-Jun;Ma, Li
我们研究了肿瘤组织分化对TCR库多样性的影响。分析了27例不同分化程度的胃肠道肿瘤患者的CD4（+）和CD8（+）T细胞亚群的CDR3谱。使用CDR3谱型复杂性评分系统来量化TCR库的多样性。每个患者都与年龄匹配的健康组相匹配，以控制年龄变异性。结果表明，复杂性评分（TCR库多样性）与肿瘤分化程度具有显著相关性，这为了解癌症患者的免疫反应提供了有用的信息。(C)2011 Elsevier Inc. All rights reserved.
We investigated the influence of tumor tissue differentiation on the diversity of TCR repertoire. CDR3 spectratypes of CD4(+) and CD8(+) T cell subsets were analyzed from 27 patients with gastrointestinal tract tumors exhibiting varying degrees of differentiation. A CDR3 spectratype complexity scoring system was used to quantify the diversity of TCR repertoire. Each patient was matched with an age-matched healthy group to control for age variability. Results show that the complexity scores (TCR repertoire diversity) have a significant correlation with the degree of tumor differentiation, which provides useful information for understanding immune response in cancer patients. (C) 2011 Elsevier Inc. All rights reserved.