Chemopreventive effects of 4-methylthio-3-butenyl isothiocyanate (Raphasatin) but not curcumin against pancreatic carcinogenesis in hamsters
Chemopreventive effects of 4-methylthio-3-butenyl isothiocyanate (Raphasatin) but not curcumin against pancreatic carcinogenesis in hamsters
复制标题
4-甲硫基-3-丁烯基异硫氰酸酯（Raphasatin）而非姜黄素对仓鼠胰腺癌的化学预防作用
DOI：
10.1021/jf3003174
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发表时间：
2013
影响因子：
6.1
通讯作者：
and Ogawa K
中科院分区：
文献类型：
--
作者：
Okamura T;Umemura T;Inoue T;Tasaki M;Ishii Y;Nakamura Y;Park EY;Sato K;Matsuo T;Okamoto S;Nishikawa A;and Ogawa K
研究了4-甲硫基-3-丁烯基异硫氰酸酯（MTBITC）和姜黄素对N-亚硝基双（2-氧代丙基）胺（BOP）引发的仓鼠皮肤的修饰作用。雄性6周龄叙利亚仓鼠皮下注射10 mg/kg体重（b.w.）的BOP，每周四次，并喂食补充有80 mg/kg饮食的MTBITC的饮食，相当于4.6 mg/kg b.w./起始阶段为3.8 mg/kg b.w./天，或2000 mg/kg姜黄素饮食，相当于118.8 mg/kg b.w./起始阶段为100.8 mg/kg b.w./开始后阶段给药日。与单独BOP组（85%）相比，在起始阶段给予80 mg/kg饮食MTBITC使包括非典型增生和腺癌在内的联合胰腺病变的发生率显著降低至55%（P< 0.05），但在BOP治疗后16周给予姜黄素则没有。在第二项研究中，通过在起始阶段给予700 mg/kg饮食MTBITC（相当于59.0 mg/kg b.w./kg），联合胰腺病变的多重性也显著降低至0.50 ± 0.51（P< 0.05）。与单独BOP组（1.10 ± 1.02）相比，我们的研究结果表明，天然存在的异硫氰酸MTBITC可能对BOP启动仓鼠胰腺癌发生发挥预防作用。
The modifying effects of 4-methylthio-3-butenyl isothiocyanate (MTBITC) and curcumin were investigated inN-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamsters. Male 6-week-old Syrian hamsters were subcutaneously injected with 10 mg/kg body weight (b.w.) of BOP four times a week, and fed a diet supplemented with 80 mg/kg diet of MTBITC, equivalent to 4.6 mg/kg b.w./day for the initiation stage or 3.8 mg/kg b.w./day for the postinitiation stage administration, respectively, or 2000 mg/kg diet of curcumin, equivalent to 118.8 mg/kg b.w./day for the initiation stage or 100.8 mg/kg b.w./day for the postinitiation stage administration, respectively. The incidence of combined pancreatic lesions, including atypical hyperplasias and adenocarcinomas, was significantly decreased to 55% (P< 0.05) by the 80 mg/kg diet MTBITC given during the initiation stage as compared to the BOP alone group (85%) but not by the curcumin administration at 16 weeks after the BOP-treatment. In the second study, the multiplicity of combined pancreatic lesions was also significantly decreased to 0.50 ± 0.51 (P< 0.05) by 700 mg/kg diet MTBITC given in the initiation stage (equivalent to 59.0 mg/kg b.w./day) as compared to the BOP alone group (1.10 ± 1.02). Our results indicate that the naturally occurring isothiocyanate MTBITC may exert preventive effects against BOP-initiation of hamster pancreatic carcinogenesis.