Effect of intravenous ranitidine and omeprazole on intestinal absorption of water, sodium, and macronutrients in patients with intestinal resection
Effect of intravenous ranitidine and omeprazole on intestinal absorption of water, sodium, and macronutrients in patients with intestinal resection
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DOI：
10.1136/gut.43.6.763
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发表时间：
1998-12-01
期刊：
影响因子：
24.5
通讯作者：
Mortensen, PB
中科院分区：
文献类型：
--
作者：
Jeppesen, PB;Staun, M;Mortensen, PB
背景-H-2受体阻滞剂和质子泵抑制剂减少短肠综合征患者的肠输出量。目的-评价静脉注射奥美拉唑和雷尼替丁对水、电解质、常量营养素、方法：13例粪便重量超过1.5 kg/天的患者，范围为1.7-5.7 kg/天。天和100 cm的中位小肠长度进行研究。奥美拉唑-10 mg每日两次或雷尼替丁150 mg每日两次，以随机、双盲、交叉设计给药5天，随后为3天对照期，不进行治疗。两名患者的一段结肠在继续被排除在分析，但是，没有影响的结果。结果-奥美拉唑增加肠道湿重吸收中位数相比，没有治疗和雷尼替丁（p
Background-H-2 receptor blockers and proton pump inhibitors reduce intestinal output in patients with short bowel syndrome.Aims-To evaluate the effect of intravenous omeprazole and ranitidine on water, electrolyte, macronutrient, and energy absorption in patients with intestinal resection.Methods-Thirteen patients with a faecal weight above 1.5 kg/day range 1.7-5.7 kg/day and a median small bowel length of 100 cm were studied. Omeprazole -10 mg twice daily or ranitidine 150 mg twice daily were administered for five days in a randomised, double blind, crossover design followed by a three day control period with no treatment. Two patients with a segment of colon in continuation were excluded from analysis which, however, had no influence on the results.Results-Omeprazole increased median intestinal wet weight absorption compared with no treatment and ranitidine (p