NEUROLOGICAL DIFFERENCES BETWEEN 9-YEAR-OLD CHILDREN FED BREAST-MILK OR FORMULA-MILK AS BABIES
NEUROLOGICAL DIFFERENCES BETWEEN 9-YEAR-OLD CHILDREN FED BREAST-MILK OR FORMULA-MILK AS BABIES
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DOI：
10.1016/s0140-6736(94)90692-0
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发表时间：
1994-11-12
期刊：
影响因子：
168.9
通讯作者：
BOERSMA, ER
中科院分区：
文献类型：
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作者：
LANTING, CI;FIDLER, V;BOERSMA, ER
轻微神经功能障碍的存在与学龄儿童的行为和认知发展有关。我们以前已经证明了轻微的神经功能障碍与围产期疾病，特别是异常的新生儿神经状况之间的关系。我们现在调查了母乳喂养和长期神经发育之间的关系。我们研究了135名母乳喂养(大于或等于3周)和391名配方奶喂养的儿童，他们是1975年至1979年在格罗宁根大学医院出生的足月儿。使用标准的新生儿神经系统检查将婴儿分为正常(247例)、轻微异常(213例)或明显异常(66例)。在9岁时，这些孩子接受了复查。1993年，他们的母亲被要求完成一份关于这些孩子在婴儿时期是如何喂养的问卷。在调整了产科、围产期、新生儿的神经和社会差异后，发现母乳喂养对9岁时的神经状态有轻微的有利影响(神经异常的优势比为0.54[95%可信区间0.30-0.97])。虽然回顾设计不能得出明确的结论，但我们的数据表明母乳喂养对出生后神经发育有有利影响。长链多不饱和脂肪酸存在于母乳中，但不存在于大多数配方奶中，它可能起到一定的作用，因为它们对大脑发育至关重要。
The presence of minor neurological dysfunction is associated with behavioural and cognitive development at school age. We have previously shown a relation between minor neurological dysfunction and perinatal disorders, especially abnormal neonatal neurological condition. We have now investigated the relation between breastfeeding and long-term neurological development.We studied 135 breastfed (for greater than or equal to 3 weeks) and 391 formula-fed children, born at term in the University Hospital Groningen between 1975 and 1979. A standard neonatal neurological examination was used to classify the infants as normal (247), slightly abnormal (213), or frankly abnormal (66). At 9 years of age the children were reexamined. In 1993 their mothers were asked to complete a questionnaire about how the children were fed as infants. After adjustment for obstetric, perinatal, neonatal neurological, and social differences, a small advantageous effect of breastfeeding on neurological status at 9 years of age was found (odds ratio for neurological non-normality 0.54 [95% Cl 0.30-0.97]).Although a retrospective design cannot lead to definite conclusions, our data suggest a beneficial effect of breastfeeding on postnatal neurological development. Longer-chain polyunsaturated fatty acids, which are present in breast-milk but not in most formula-milks, may have a role since they are vital for brain development.