Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization.
Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization.
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间充质干细胞衍生的细胞外囊泡通过支持巨噬细胞极化改变疾病结果
DOI：
10.1186/s13287-020-01937-8
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发表时间：
2020-09-29
影响因子：
7.5
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Wang J;Xia J;Huang R;Hu Y;Fan J;Shu Q;Xu J
间充质干细胞（MSC）是存在于几乎所有出生后组织中的成体基质细胞。由于其再生和免疫调节能力，MSC在过去二十年中引起了越来越多的关注。MSC衍生的细胞外囊泡（MSC-EV）能够通过将功能蛋白和遗传物质转移到受体细胞而不与细胞接触来复制其亲本细胞的作用。MSC-EV还靶向巨噬细胞，巨噬细胞在先天免疫、适应性免疫和体内平衡中发挥重要作用。最近的研究表明，MSC-EV在各种环境中减少M1极化和/或促进M2极化。在这篇综述中，我们讨论了巨噬细胞极化的机制和MSC-EV诱导的巨噬细胞极化在心血管，肺，消化，肾和中枢神经系统疾病的结果中的作用。总之，MSC-EV可能成为MSC治疗炎症和免疫起关键作用的疾病的可行替代品。
Mesenchymal stem cells (MSCs) are adult stromal cells that reside in virtually all postnatal tissues. Due to their regenerative and immunomodulatory capacities, MSCs have attracted growing attention during the past two decades. MSC-derived extracellular vesicles (MSC-EVs) are able to duplicate the effects of their parental cells by transferring functional proteins and genetic materials to recipient cells without cell-to-cell contact. MSC-EVs also target macrophages, which play an essential role in innate immunity, adaptive immunity, and homeostasis. Recent studies have demonstrated that MSC-EVs reduce M1 polarization and/or promote M2 polarization in a variety of settings. In this review, we discuss the mechanisms of macrophage polarization and roles of MSC-EV-induced macrophage polarization in the outcomes of cardiovascular, pulmonary, digestive, renal, and central nervous system diseases. In conclusion, MSC-EVs may become a viable alternative to MSCs for the treatment of diseases in which inflammation and immunity play a critical role.
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DOI：
10.4049/jimmunol.1202496
发表时间：
2013-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banerjee S;Xie N;Cui H;Tan Z;Yang S;Icyuz M;Abraham E;Liu G
通讯作者：
Liu G
鼻息肉衍生的间充质基质细胞表现出缺乏免疫相关的分子和高水平的茎/祖细胞标记。
影响因子：
7.3
作者：
de Oliveira PW;Pezato R;Agudelo JS;Perez-Novo CA;Berghe WV;Câmara NO;de Almeida DC;Gregorio LC
通讯作者：
Gregorio LC
影响因子：
4.4
作者：
Biswas, Subir;Mandal, Gunjan;Bhattacharyya, Arindam
通讯作者：
Bhattacharyya, Arindam
影响因子：
9
作者：
Gao, Xiao;Xiong, Ye;Li, Gang
通讯作者：
Li, Gang
影响因子：
7.3
作者：
Carreras-Planella, Laura;Monguio-Tortajada, Marta;Franquesa, Marcella
通讯作者：
Franquesa, Marcella