Polyploidy and cancer; the desoxypentosenucleic acid content of nuclei of normal, precancerous, and neoplastic rat tissues.
Polyploidy and cancer; the desoxypentosenucleic acid content of nuclei of normal, precancerous, and neoplastic rat tissues.
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DOI：
10.1085/jgp.34.1.59
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发表时间：
1950-09
期刊：
影响因子：
--
通讯作者：
LUCK JM
中科院分区：
文献类型：
--
作者：
CUNNINGHAM L;GRIFFIN AC;LUCK JM
测定大鼠各种正常组织和肿瘤组织以及显示癌前病变的肝脏的单个细胞核的平均脱氧戊糖核酸含量。除了某些归因于多倍性的例外情况，这些值实际上彼此之间以及与其他哺乳动物细胞核报告的值之间无法区分。大鼠二倍体细胞中该核酸的含量似乎是恒定的，几乎等于6 x 10-6微克。因此，在显示癌前或肿瘤变化的组织中发现该核酸浓度增加，证实了在此类组织中细胞结构和多倍性增加的组织学观察结果。
The average desoxypentosenucleic acid content of individual nuclei was determined for various normal and tumor tissues, and for livers showing precancerous changes, in the rat. With certain exceptions attributable to polyploidy, the values were practically indistinguishable from each other and from values reported for cell nuclei of other mammals. The amount of this nucleic acid in diploid cells of the rat appears to be a constant, nearly equal to 6 x 10–6 micrograms. Findings of increased concentrations of this nucleic acid in tissues showing preneoplastic or neoplastic changes therefore confirm histological observations of increased cellularity and polyploidy in such tissues.